Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 7/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16417566 | 0.75 | LATS1 (0.38) | LMNACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL23486244 | 0.71 | MAPK9 (0.39) | KDM4AKDM4BKDM5CKDM4CKDM5B | |
| SCHEMBL15935230 | 0.71 | LATS1 (0.36) | KDM4AKDM4BKDM5CKDM4CKDM5B | |
| Hydrochloric Acid SCHEMBL6648426 | 0.70 | RAB9A (0.46) | LMNACYP1A2ACHEIDO1TDO2 | |
| SCHEMBL15922137 | 0.68 | KMT2A (0.41) | LMNAACHE | |
| SCHEMBL2392643 | 0.67 | EPHX2 (0.43) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2144895 | 0.65 | BACE1 (0.42) | CYP1A2CYP2C19ACHEIDO1 | |
| SCHEMBL21596940 | 0.65 | ENPP2 (0.45) | LMNAGAA | |
| SCHEMBL11202057 | 0.64 | KDM4C (0.43) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3811981 | 0.64 | NCF1 (0.57) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014100734-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |