Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2036918 | 0.88 | JAK2 (0.43) | LRRK2JAK2MAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL27866404 | 0.67 | TRPA1 (0.53) | HIF1AJAK2MAPTTRPA1KDM4E | |
| SCHEMBL25515775 | 0.67 | HDAC6 (0.48) | JAK2MAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL30408728 | 0.67 | HDAC6 (0.48) | JAK2MAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL13122324 | 0.66 | MAP2K4 (0.56) | TRPA1MAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL29584191 | 0.66 | LRRK2 (0.52) | LRRK2 | |
| SCHEMBL4782691 | 0.66 | LRRK2 (0.52) | LRRK2 | |
| SCHEMBL19188029 | 0.65 | JAK2 (0.57) | LRRK2JAK2MAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL1583722 | 0.64 | MET (0.64) | POLBSMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL27968550 | 0.63 | MKNK1 (0.71) | JAK2MAP2K4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2485726-A1 | FLUORO-SUBSTITUTED 3,5-DICYANO-4-(1H-INDAZOL-5-YL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2012-08-15 | — | — | EP | claimed |
| WO-2011042368-A1 | FLUORO-SUBSTITUTED 3,5-DICYANO-4-(1H-INDAZOL-5-YL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-04-14 | — | — | WO | claimed |