Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.40 |
| ▸ | HTR3B | O95264 | 4/20 | 0.40 |
| ▸ | HTR3A | P46098 | 4/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29955248 | 0.98 | HSD11B1 (0.44) | HSD11B1PDE10ATRPV3HTR3EHTR3B | |
| SCHEMBL15845742 | 0.84 | GAA (0.51) | PDE10AALDH1A1MAPTMAPK1POLB | |
| SCHEMBL2120559 | 0.84 | HTR3A (0.60) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2553138 | 0.82 | MAPT (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2559110 | 0.80 | MAP4K4 (0.49) | ALDH1A1MAPTMAPK1KDM4EL3MBTL1 | |
| SCHEMBL15918558 | 0.80 | HTR3E (0.50) | HSD11B1PDE10ATRPV3HTR3EHTR3B | |
| SCHEMBL6242988 | 0.78 | HSD11B1 (0.50) | HSD11B1PDE10ATRPV3HTR3EHTR3B | |
| SCHEMBL6838679 | 0.78 | HSD11B1 (0.50) | HSD11B1PDE10ATRPV3HTR3EHTR3B | |
| SCHEMBL2559839 | 0.77 | PDE10A (0.42) | PDE10AHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL31334907 | 0.76 | PARP1 (0.44) | PDE10AALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-9656971-B2 | COMT inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2017-05-23 | — | — | US | disclosed |
| EP-2938600-B1 | COMT INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-01-25 | — | — | EP | disclosed |
| US-20160002177-A1 | COMT INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2016-01-07 | — | — | US | disclosed |
| EP-2938600-A1 | COMT INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-11-04 | — | — | EP | disclosed |
| WO-2014102233-A1 | COMT INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002177-A1 | COMT INHIBITORS | COMT, PNMT, SLC6A3 | HSD11B1 263/4885PDE10A 989/4885TRPV3 4475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.