SCHEMBL15847166

SCHEMBL15847166

CCSc1cc(C(F)(F)F)cnc1C#N

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.56
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.54
GAA P10253 3/20 0.38
HTT P42858 1/20 0.38
AR P10275 5/20 0.36
AGBL2 Q5U5Z8 1/20 0.34
MAPK1 P28482 1/20 0.33
CTSK P43235 3/20 0.33
CTSS P25774 2/20 0.33
NPSR1 Q6W5P4 1/20 0.33
MAPT P10636 1/20 0.32
CRHBP P24387 1/20 0.32
CRHR2 Q13324 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
DDR1 Q08345 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31267241 0.84 ALDH1A1 (0.39) ALDH1A1MEN1KMT2ASMN1; SMN2MAPK1
SCHEMBL20867390 0.80 MAPK1 (0.36) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL26121696 0.79 ALDH1A1 (0.50) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL20867084 0.78 SMN1; SMN2 (0.40) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL20885615 0.78 AGBL2 (0.41) ALDH1A1MEN1KMT2ASMN1; SMN2AGBL2
SCHEMBL20994335 0.78 SMN1; SMN2 (0.40) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL23642509 0.76 MAPK1 (0.36) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL17514093 0.76 MAPK1 (0.36) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL31267262 0.76 MAPK1 (0.36) ALDH1A1MEN1KMT2ASMN1; SMN2HTT
SCHEMBL17504814 0.76 AGBL2 (0.36) ALDH1A1MEN1KMT2ASMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220104496-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2022-04-07 US disclosed
US-11229208-B2 Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents SYNGENTA PARTICIPATIONS AG (CH) 2022-01-25 US disclosed
US-10939682-B2 Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents SYNGENTA PARTICIPATIONS AG (CH) 2021-03-09 US disclosed
EP-3778599-A2 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2021-02-17 EP disclosed
EP-3778598-A2 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2021-02-17 EP disclosed
US-20210037827-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2021-02-11 US disclosed
CN-107652292-B Pesticidally active bicyclic or tricyclic heterocycles with sulfur-containing substituents 先正达参股股份有限公司 2020-11-17 CN disclosed
EP-3016949-B1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2020-05-13 EP disclosed
EP-2938601-B1 FUSED OXAZOLE COMPOUNDS AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL CO (JP) 2018-05-16 EP disclosed
EP-2938601-B1 FUSED OXAZOLE COMPOUNDS AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL CO (JP) 2018-05-16 EP disclosed
US-9615580-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-04-11 US disclosed
US-20160255837-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2016-09-08 US disclosed
EP-3016949-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS Syngenta Participations AG (CH) 2016-05-11 EP disclosed
CN-105431433-A Pesticidally active bicyclic or tricyclic heterocycles with sulfur-containing substituents SYNGENTA PARTICIPATIONS AG 2016-03-23 CN disclosed
WO-2016012395-A1 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2016-01-28 WO disclosed
US-20150313234-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-11-05 US disclosed
US-20150313234-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-11-05 US disclosed
EP-2938601-A1 FUSED OXAZOLE COMPOUNDS AND USE THEREOF FOR PEST CONTROL Sumitomo Chemical Company Limited (JP) 2015-11-04 EP disclosed
WO-2015000715-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA PARTICIPATIONS AG (CH) 2015-01-08 WO disclosed
WO-2014104407-A1 FUSED OXAZOLE COMPOUNDS AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-07-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220104496-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS GSTA1, CYP1B1, DDT ALDH1A1 149/4885MEN1 688/4885KMT2A 3319/4885
US-20160255837-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS DDT, TST, SCLY ALDH1A1 2859/4885MEN1 2257/4885KMT2A 2334/4885
US-20210037827-A1 PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS GSTA1, CYP1B1, DDT ALDH1A1 149/4885MEN1 688/4885KMT2A 3319/4885
US-10939682-B2 Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents DDT, TST, SCLY ALDH1A1 2859/4885MEN1 2257/4885KMT2A 2334/4885
US-11229208-B2 Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents GSTA1, CYP1B1, DDT ALDH1A1 149/4885MEN1 688/4885KMT2A 3319/4885
US-20150313234-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL AFF1, AFF2, PYM1 ALDH1A1 1355/4885MEN1 467/4885KMT2A 807/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.