Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14870882 | 0.70 | NPC1 (0.52) | ALDH1A1LMNAKDM4EGAAFDPS | |
| SCHEMBL28181288 | 0.67 | — | — | |
| SCHEMBL28106387 | 0.67 | MTNR1A (0.38) | ALDH1A1LMNAMAPK1 | |
| SCHEMBL14723762 | 0.66 | RAB9A (0.52) | ALDH1A1HTTKDM4EGAAFDPS | |
| SCHEMBL2174053 | 0.65 | ALDH1A1 (0.53) | ALDH1A1LMNAHTTKDM4EGAA | |
| SCHEMBL24015602 | 0.62 | KCNH3 (0.33) | ALDH1A1P2RX7 | |
| SCHEMBL2101378 | 0.61 | — | — | |
| SCHEMBL968195 | 0.61 | — | — | |
| SCHEMBL13388758 | 0.61 | — | — | |
| SCHEMBL23566413 | 0.61 | LMNA (0.56) | ALDH1A1LMNAHTTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1030606-C | Alkoxy-1, 2, 3-triazolo [1, 5-C ] pyrimidine-2-sulfonamides, their preparation and their use | DOW CHEMICAL CO (US) | 1996-01-03 | — | — | CN | claimed |
| CN-1106010-A | Alkoxy-1,2,4-triazolo[1,5-c]pyrimidine-2-sulfonamides, process for their preparation and intermediates | DOW CHEMICAL CO (US) | 1995-08-02 | — | — | CN | claimed |
| CN-1039590-A | Alkoxy-1, 2, 4-triazolo [1, 5-C ] pyrimidine-2-sulfonamides, processes for their preparation and intermediates | DOW CHEMICAL CO (US) | 1990-02-14 | — | — | CN | claimed |
| WO-2014104904-A1 | PROCESS FOR PREPARATION OF BOSENTAN MONOHYDRATE OF PHARMACEUTICAL PURITY | INSTYTUT FARMACEUTYCZNY (PL) | 2014-07-03 | — | — | WO | disclosed |
| CN-1243514-A | Sulfonamide derivatives | KOREA RES INST CHEM TECH (KR) | 2000-02-02 | — | — | CN | disclosed |
| CN-1030606-C | Alkoxy-1, 2, 3-triazolo [1, 5-C ] pyrimidine-2-sulfonamides, their preparation and their use | DOW CHEMICAL CO (US) | 1996-01-03 | — | — | CN | disclosed |
| CN-1106010-A | Alkoxy-1,2,4-triazolo[1,5-c]pyrimidine-2-sulfonamides, process for their preparation and intermediates | DOW CHEMICAL CO (US) | 1995-08-02 | — | — | CN | disclosed |
| CN-1039590-A | Alkoxy-1, 2, 4-triazolo [1, 5-C ] pyrimidine-2-sulfonamides, processes for their preparation and intermediates | DOW CHEMICAL CO (US) | 1990-02-14 | — | — | CN | disclosed |
| CN-1039590-A | Alkoxy-1, 2, 4-triazolo [1, 5-C ] pyrimidine-2-sulfonamides, processes for their preparation and intermediates | DOW CHEMICAL CO (US) | 1990-02-14 | — | — | CN | disclosed |
| CN-1039590-A | Alkoxy-1, 2, 4-triazolo [1, 5-C ] pyrimidine-2-sulfonamides, processes for their preparation and intermediates | DOW CHEMICAL CO (US) | 1990-02-14 | — | — | CN | disclosed |