SCHEMBL158484

SCHEMBL158484

NCCOCCOCCNC(=O)CCC(=O)O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 5/20 0.44
CA12 O43570 4/20 0.44
CA1 P00915 4/20 0.44
CA4 P22748 4/20 0.44
CA9 Q16790 4/20 0.44
CA14 Q9ULX7 4/20 0.44
KDM4E B2RXH2 3/20 0.41
KDM5C P41229 3/20 0.41
PHF8 Q9UPP1 3/20 0.41
KDM2A Q9Y2K7 3/20 0.41
SMN1; SMN2 Q16637 1/20 0.39
KMT2A Q03164 3/20 0.38
MEN1 O00255 1/20 0.38
EGLN1 Q9GZT9 2/20 0.38
KDM6B O15054 1/20 0.38
FOLH1 Q04609 1/20 0.38
EPOR P19235 1/20 0.37
ECE1 P42892 1/20 0.36
ADORA3 P0DMS8 1/20 0.35
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23157565 1.00 CA2 (0.44) CA2CA12CA1CA4CA9
SCHEMBL23157519 1.00 CA2 (0.44) CA2CA12CA1CA4CA9
SCHEMBL23157585 1.00 CA2 (0.44) CA2CA12CA1CA4CA9
SCHEMBL2323385 0.98 CA2 (0.42) CA2CA12CA1CA4CA9
SCHEMBL19172671 0.93 CA2 (0.49) CA2CA12CA1CA4CA9
SCHEMBL23158185 0.91 CA2 (0.40) CA2CA12CA1CA4CA9
SCHEMBL17447162 0.91 CA2 (0.40) CA2CA12CA1CA4CA9
SCHEMBL15728323 0.91 CA12 (0.46) CA2CA12CA1CA4CA9
SCHEMBL29896372 0.91 CA12 (0.46) CA2CA12CA1CA4CA9
SCHEMBL23157878 0.90 TSHR (0.43) CA2CA12CA1CA4CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3453711-B1 LLP2A- BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT UNIV CALIFORNIA (US) 2021-08-18 EP claimed
US-20200369723-A1 LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-11-26 US claimed
EP-3453711-A1 LLP2A- BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT The Regents of the University of California (US) 2019-03-13 EP claimed
EP-2753626-B1 LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT UNIV CALIFORNIA (US) 2018-08-08 EP claimed
US-20170174722-A1 LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-06-22 US claimed
US-9561256-B2 LLP2A-bisphosphonate conjugates for osteoporosis treatment THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-02-07 US claimed
US-20160074461-A1 LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2016-03-17 US claimed
US-9119884-B2 LLP2A-bisphosphonate conjugates for osteoporosis treatment THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-09-01 US claimed
US-20140056855-A1 LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-02-27 US claimed
WO-2013032527-A1 LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-03-07 WO claimed
WO-2012031228-A2 LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-03-08 WO claimed
US-12559529-B2 NPY2 receptor agonists BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2026-02-24 US disclosed
US-20260015399-A1 SOLUBLE NPY2 RECEPTOR AGONISTS BOEHRINGER INGELHEIM INT (DE) 2026-01-15 US disclosed
US-12391737-B2 Soluble NPY2 receptor agonists BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2025-08-19 US disclosed
CN-112672747-B Peptides for activating cell signaling in osteoprogenitor cells 加利福尼亚大学董事会 2025-02-18 CN disclosed
WO-2009115469-A1 PROTEASE STABILIZED, ACYLATED INSULIN ANALOGUES NOVO NORDISK A/S (DK) 2009-09-24 WO disclosed
US-7576175-B2 Amino acid terminated diphenylurea derivatives; display high binding affinity, specificity, and stability; use in treating cancer, inflammatory diseases, and autoimmune diseases THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-08-18 US disclosed
WO-2009022006-A1 INSULINS WITH AN ACYL MOIETY COMPRISING REPEATING UNITS OF ALKYLENE GLYCOL CONTAINING AMINO ACIDS NOVO NORDISK A/S (DK) 2009-02-19 WO disclosed
US-20060019900-A1 Alpha-4 beta-1 integrin ligands for imaging and therapy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-01-26 US disclosed
US-20060019900-A1 Alpha-4 beta-1 integrin ligands for imaging and therapy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060019900-A1 Alpha-4 beta-1 integrin ligands for imaging and therapy ITGA4, ITGB4, ITGA1 CA2 4144/4885CA12 2713/4885CA1 2626/4885
US-20170174722-A1 LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT LCP1, BST2, ITGA2B CA2 3873/4885CA12 4199/4885CA1 4637/4885
US-20200369723-A1 LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT LCP1, BST2, ITGA2B CA2 3873/4885CA12 4199/4885CA1 4637/4885
US-20140056855-A1 LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT LCP1, BST2, ITGA2B CA2 3873/4885CA12 4199/4885CA1 4637/4885
US-20160074461-A1 LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT LCP1, BST2, ITGA2B CA2 3873/4885CA12 4199/4885CA1 4637/4885
US-12391737-B2 Soluble NPY2 receptor agonists NPY2R, NPY1R, NPY5R CA2 1305/4885CA12 2621/4885CA1 3171/4885
US-20260015399-A1 SOLUBLE NPY2 RECEPTOR AGONISTS NPY1R, NPY2R, NPY5R CA2 700/4885CA12 1835/4885CA1 1432/4885
US-12559529-B2 NPY2 receptor agonists NPY2R, NPY5R, NPY1R CA2 1625/4885CA12 2728/4885CA1 4390/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.