Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Butoxyethanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9500948 | 0.94 | ALDH1A1 (0.47) | TSHRHTTMAPTALDH1A1PLA2G2C | |
| Ethylene SCHEMBL18151800 | 0.91 | ALDH1A1 (0.45) | TSHRHTTMAPTALDH1A1PLA2G2C | |
| Di(Hydroxyethyl)Ether SCHEMBL4283930 | 0.91 | ALDH1A1 (0.50) | TSHRMEN1KMT2AHTTMAPT | |
| Di(Hydroxyethyl)Ether SCHEMBL10480450 | 0.91 | ALDH1A1 (0.50) | TSHRMEN1KMT2AHTTMAPT | |
| Tetraethylene Glycol SCHEMBL3062384 | 0.89 | ALDH1A1 (0.49) | TSHRMEN1KMT2AHTTMAPT | |
| Pentaethylene Glycol SCHEMBL3466434 | 0.89 | ALDH1A1 (0.49) | TSHRMEN1KMT2AHTTMAPT | |
| Tetraethylene Glycol SCHEMBL1145155 | 0.89 | ALDH1A1 (0.49) | TSHRMEN1KMT2AHTTMAPT | |
| Hexaethylene Glycol SCHEMBL4379136 | 0.89 | ALDH1A1 (0.49) | TSHRMEN1KMT2AHTTMAPT | |
| Triethylene Glycol SCHEMBL6130636 | 0.89 | ALDH1A1 (0.49) | TSHRMEN1KMT2AHTTMAPT | |
| Hexaethylene Glycol SCHEMBL11280667 | 0.89 | ALDH1A1 (0.49) | TSHRMEN1KMT2AHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10840397-B2 | Highly-fluorescent and photo-stable chromophores for wavelength conversion | NITTO DENKO CORPORATION (JP) | 2020-11-17 | — | — | US | disclosed |
| US-10461201-B2 | Highly-fluorescent and photo-stable chromophores for wavelength conversion | NITTO DENKO CORPORATION (JP) | 2019-10-29 | — | — | US | disclosed |
| US-20180248053-A1 | HIGHLY-FLUORESCENT AND PHOTO-STABLE CHROMOPHORES FOR WAVELENGTH CONVERSION | NITTO DENKO CORP (JP) | 2018-08-30 | — | — | US | disclosed |
| US-9960294-B2 | Highly fluorescent and photo-stable chromophores for wavelength conversion | NITTO DENKO CORPORATION (JP) | 2018-05-01 | — | — | US | disclosed |
| EP-2941474-B1 | HIGHLY-FLUORESCENT AND PHOTO-STABLE CHROMOPHORES FOR WAVELENGTH CONVERSION | NITTO DENKO CORP (JP) | 2018-02-28 | — | — | EP | disclosed |
| US-20150340519-A1 | HIGHLY-FLUORESCENT AND PHOTO-STABLE CHROMOPHORES FOR WAVELENGTH CONVERSION | NITTO DENKO CORPORATION (JP) | 2015-11-26 | — | — | US | disclosed |
| EP-2941474-A2 | HIGHLY-FLUORESCENT AND PHOTO-STABLE CHROMOPHORES FOR WAVELENGTH CONVERSION | Nitto Denko Corporation (JP) | 2015-11-11 | — | — | EP | disclosed |
| WO-2014107606-A2 | HIGHLY-FLUORESCENT AND PHOTO-STABLE CHROMOPHORES FOR WAVELENGTH CONVERSION | NITTO DENKO CORPORATION (JP) | 2014-07-10 | — | — | WO | disclosed |