Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15869849 | 0.89 | MAPT (0.48) | FAAHTP53MAPTPOLBTDP1 | |
| SCHEMBL15869846 | 0.87 | FAAH (0.48) | FAAHTP53MAPTPOLBTDP1 | |
| SCHEMBL14800200 | 0.86 | MAPT (0.53) | FAAHTP53MAPTPOLBTDP1 | |
| SCHEMBL14800388 | 0.82 | FAAH (0.45) | FAAHTP53MAPTPOLBTDP1 | |
| SCHEMBL14799953 | 0.81 | MARS1 (0.49) | FAAHTP53MAPTTDP1KMT2A | |
| SCHEMBL21607427 | 0.81 | FAAH (0.44) | FAAHTP53MAPTPOLBTDP1 | |
| SCHEMBL14800012 | 0.81 | FAAH (0.44) | FAAHTP53MAPTPOLBTDP1 | |
| SCHEMBL15862431 | 0.78 | ALDH1A1 (0.47) | TP53MAPTKMT2AALDH1A1HSD17B10 | |
| SCHEMBL21605634 | 0.77 | FAAH (0.43) | FAAHTP53MAPTPOLBTDP1 | |
| SCHEMBL15868155 | 0.74 | MAPT (0.44) | FAAHMAPTTDP1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9078899-B2 | Pyrazolyl-based carboxamides II | GRUENENTHAL GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| US-9078899-B2 | Pyrazolyl-based carboxamides II | GRUENENTHAL GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| WO-2014108336-A1 | PYRAZOLYL-BASED CARBOXAMIDES II AS CRAC CHANNEL INHIBITORS | Grünenthal GmbH (DE) | 2014-07-17 | — | — | WO | disclosed |
| US-20140194452-A1 | Pyrazolyl-Based Carboxamides II | Grünenthal GmbH (DE) | 2014-07-10 | — | — | US | disclosed |
| US-20140194452-A1 | Pyrazolyl-Based Carboxamides II | Grünenthal GmbH (DE) | 2014-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194452-A1 | Pyrazolyl-Based Carboxamides II | AADAC, VDAC2, NLRP3 | FAAH 1408/4885TP53 2705/4885MAPT 3740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.