Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | KLK7 | P49862 | 6/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.42 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL582271 | 1.00 | NR1H2 (0.53) | NR1H2NR1H3PARP1DPP4HDAC1 | |
| SCHEMBL15353299 | 1.00 | NR1H2 (0.53) | NR1H2NR1H3PARP1DPP4HDAC1 | |
| SCHEMBL18589365 | 0.88 | OPRK1 (0.43) | NR1H2NR1H3PARP1STS | |
| SCHEMBL15358971 | 0.88 | CCR3 (0.44) | NR1H2NR1H3PARP1DPP4 | |
| SCHEMBL582498 | 0.88 | OPRK1 (0.43) | NR1H2NR1H3PARP1STS | |
| SCHEMBL29997923 | 0.84 | NR1H2 (0.50) | NR1H2NR1H3PARP1DPP4HDAC1 | |
| SCHEMBL28334137 | 0.84 | NR1H2 (0.56) | NR1H2NR1H3PARP1DPP4HDAC1 | |
| SCHEMBL28334140 | 0.84 | NR1H2 (0.56) | NR1H2NR1H3PARP1DPP4HDAC1 | |
| SCHEMBL28052129 | 0.84 | JAK2 (0.45) | NR1H2NR1H3PARP1STSJAK2 | |
| SCHEMBL14630965 | 0.84 | PSEN1 (0.53) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9115151-B2 | Substituted 2,10-dihydro-9-oxa-1,2,4A-triazaphenanthren-3-ones and uses thereof | ABBVIE INC. (US) | 2015-08-25 | — | — | US | disclosed |
| US-20140206663-A1 | TRIAZINONE COMPOUNDS | WUXI APPTECH (SHANGHAI) CO., LTD. (CN) | 2014-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140206663-A1 | TRIAZINONE COMPOUNDS | THPO, IL5, CYP11B2 | NR1H2 211/4885NR1H3 311/4885PARP1 1420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.