SCHEMBL15901459

SCHEMBL15901459

OCc1cc(F)c(Oc2ccnc(C(F)(F)F)c2)c(F)c1

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 2/20 0.42
LOX P28300 1/20 0.41
ALOX5AP P20292 2/20 0.40
FEN1 P39748 2/20 0.40
RIPK2 O43353 1/20 0.38
KDR P35968 1/20 0.36
GCK P35557 1/20 0.36
TGFBR1 P36897 3/20 0.35
PLA2G7 Q13093 4/20 0.34
TRPV3 Q8NET8 1/20 0.33
KIF11 P52732 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29769062 1.00 LOXL2 (0.42) LOXL2LOXALOX5APFEN1RIPK2
SCHEMBL30753333 0.91 LOXL2 (0.38) LOXL2LOXALOX5APFEN1RIPK2
SCHEMBL24998894 0.89 LOXL2 (0.40) LOXL2LOXALOX5APFEN1RIPK2
SCHEMBL29769056 0.89 LOXL2 (0.40) LOXL2LOXALOX5APFEN1RIPK2
SCHEMBL21098839 0.89 GCK (0.38) LOXL2ALOX5APFEN1RIPK2KDR
SCHEMBL19124891 0.86 LOXL2 (0.42) LOXL2LOXALOX5APFEN1RIPK2
SCHEMBL30997488 0.86 LOXL2 (0.42) LOXL2LOXALOX5APFEN1RIPK2
SCHEMBL30753296 0.85 KDR (0.33) ALOX5APFEN1RIPK2KDRGCK
SCHEMBL23193922 0.84 PLA2G7 (0.40) LOXL2LOXALOX5APFEN1RIPK2
SCHEMBL14662000 0.84 KDR (0.46) LOXL2LOXALOX5APFEN1KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748841-A1 BICYCLO[5,6] IMIDAZOLE PYRIMIDONE DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF Shujing Biopharma Co., Ltd (CN) 2026-05-27 EP disclosed
US-20250154153-A1 DIHYDROIMIDAZO-PYRIMIDINONE COMPOUNDS AS LP-PLA2 INHIBITORS AND USE THEREOF 4B TECHNOLOGIES (BEIJING) CO., LIMITED (CN) 2025-05-15 US disclosed
WO-2025015951-A1 BICYCLO[5,6] IMIDAZOLE PYRIMIDONE DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF 上海枢境生物科技有限公司 2025-01-23 WO disclosed
US-20240300965-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2024-09-12 US disclosed
CN-118221687-A Bicyclo [5,6] imidazole pyrimidinone derivative, preparation method and application thereof 上海枢境生物科技有限公司 2024-06-21 CN disclosed
US-11999746-B2 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2024-06-04 US disclosed
US-20230357268-A1 PREPARATION AND APPLICATION OF TRICYCLIC PYRIMIDINONE COMPOUND AND ITS COMPOSITION NEUSCO BIOTECH LIMITED (CN) 2023-11-09 US disclosed
US-20230357268-A1 PREPARATION AND APPLICATION OF TRICYCLIC PYRIMIDINONE COMPOUND AND ITS COMPOSITION NEUSCO BIOTECH LIMITED (CN) 2023-11-09 US disclosed
US-20230271980-A1 PREPARATION AND APPLICATION OF TRICYCLIC PYRIMIDINONE COMPOUND AND ITS COMPOSITION NEUSCO BIOTECH LIMITED (CN) 2023-08-31 US disclosed
US-20230271980-A1 PREPARATION AND APPLICATION OF TRICYCLIC PYRIMIDINONE COMPOUND AND ITS COMPOSITION NEUSCO BIOTECH LIMITED (CN) 2023-08-31 US disclosed
EP-2948456-A1 BICYCLIC PYRIMIDONE COMPOUNDS AS INHIBITORS OF LP-PLA2 GlaxoSmithKline Intellectual Property Development Limited (GB) 2015-12-02 EP disclosed
US-9051325-B2 Bicyclic [5,6] imidazo pyrimodone compounds for use in the treatment of diseases or conditions mediated by Lp-PLA2 GLAXO GROUP LIMITED (GB) 2015-06-09 US disclosed
US-9051325-B2 Bicyclic [5,6] imidazo pyrimodone compounds for use in the treatment of diseases or conditions mediated by Lp-PLA2 GLAXO GROUP LIMITED (GB) 2015-06-09 US disclosed
US-9051325-B2 Bicyclic [5,6] imidazo pyrimodone compounds for use in the treatment of diseases or conditions mediated by Lp-PLA2 GLAXO GROUP LIMITED (GB) 2015-06-09 US disclosed
WO-2014114249-A1 BICYCLIC PYRIMIDONE COMPOUNDS AS INHIBITORS OF LP-PLA2 GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2014-07-31 WO disclosed
WO-2014114249-A1 BICYCLIC PYRIMIDONE COMPOUNDS AS INHIBITORS OF LP-PLA2 GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2014-07-31 WO disclosed
WO-2014114694-A1 2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2014-07-31 WO disclosed
US-20140213599-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2014-07-31 US disclosed
US-20140213599-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2014-07-31 US disclosed
WO-2014114694-A1 2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2014-07-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140213599-A1 COMPOUNDS LPCAT1, PLA2G7, PLAAT2 LOXL2 147/4885LOX 118/4885ALOX5AP 37/4885
US-20250154153-A1 DIHYDROIMIDAZO-PYRIMIDINONE COMPOUNDS AS LP-PLA2 INHIBITORS AND USE THEREOF PLA2G4A, PLA2G1B, PLA2G4B LOXL2 199/4885LOX 159/4885ALOX5AP 63/4885
US-20240300965-A1 COMPOUNDS PLAAT2, PLA2G12A, PLA2G1B LOXL2 210/4885LOX 151/4885ALOX5AP 40/4885
US-11999746-B2 Compounds PLAAT2, PLA2G12A, PLA2G1B LOXL2 210/4885LOX 151/4885ALOX5AP 40/4885
US-20230271980-A1 PREPARATION AND APPLICATION OF TRICYCLIC PYRIMIDINONE COMPOUND AND ITS COMPOSITION PLA2G1B, PLA2G4B, PLA2G4A LOXL2 195/4885LOX 146/4885ALOX5AP 60/4885
US-20230357268-A1 PREPARATION AND APPLICATION OF TRICYCLIC PYRIMIDINONE COMPOUND AND ITS COMPOSITION PLA2G1B, PLA2G4B, PLA2G5 LOXL2 241/4885LOX 193/4885ALOX5AP 57/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.