Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PYGL | P06737 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PLD2 | O14939 | 2/20 | 0.44 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6361487 | 0.84 | PTGES (0.50) | NPC1RAB9APYGLPOLBMEN1 | |
| SCHEMBL22299805 | 0.83 | HTT (0.53) | NPC1RAB9APYGLPOLBMEN1 | |
| SCHEMBL4176134 | 0.83 | CA12 (0.53) | NPC1RAB9APOLBKMT2AHDAC2 | |
| SCHEMBL16071071 | 0.81 | NPC1 (0.51) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL10254937 | 0.80 | NPC1 (0.50) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL4181930 | 0.79 | NPC1 (0.46) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL28350981 | 0.79 | NPC1 (0.49) | NPC1RAB9AMEN1KMT2ATSHR | |
| SCHEMBL7746477 | 0.79 | NPC1 (0.49) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL4164307 | 0.77 | NPC1 (0.55) | NPC1RAB9ACYP3A4VCPFFAR1 | |
| SCHEMBL4178343 | 0.77 | RAB9A (0.55) | NPC1RAB9APOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220144793-A1 | WATER-SOLUBLE YNAMIDE COUPLING REAGENT AND PREPARATION METHOD AND USE THEREOF | Xi'an Easy Peptide Biotechnology Co., Ltd. (CN) | 2022-05-12 | — | — | US | disclosed |
| US-10836707-B2 | Mild and efficient preparation method for α-acyloxyenamide compounds and use thereof in synthesis of amide and polypeptide | GUANGZHOU NEW PEPTIDE BIOMEDICAL COMPANY LIMITED (CN) | 2020-11-17 | — | — | US | disclosed |
| US-20200299226-A1 | MILD AND EFFICIENT PREPARATION METHOD FOR A-ACYLOXYENAMIDE COMPOUNDS AND USE THEREOF IN SYNTHESIS OF AMIDE AND POLYPEPTIDE | GUANGZHOU NEW PEPTIDE BIOMEDICAL COMPANY LIMITED (CN) | 2020-09-24 | — | — | US | disclosed |
| US-20190210957-A1 | MILD AND EFFICIENT PREPARATION METHOD FOR A-ACYLOXYENAMIDE COMPOUNDS AND USE THEREOF IN SYNTHESIS OF AMIDE AND POLYPEPTIDE | GUANGZHOU NEW PEPTIDE BIOMEDICAL COMPANY LIMITED (CN) | 2019-07-11 | — | — | US | disclosed |
| WO-2018018863-A1 | MILD AND EFFICIENT PREPARATION METHOD FOR Α-ACYLOXY ALKENYL AMIDE COMPOUND AND USE THEREOF IN SYNTHESIS OF AMIDE AND POLYPEPTIDE | 江西师范大学 | 2018-02-01 | — | — | WO | disclosed |
| EP-2948450-A1 | METALLOENZYME INHIBITOR COMPOUNDS | Viamet Pharmaceuticals, Inc. (US) | 2015-12-02 | — | — | EP | disclosed |
| WO-2014117090-A1 | METALLOENZYME INHIBITOR COMPOUNDS | VIAMET PHARMACEUTICALS, INC. (US) | 2014-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190210957-A1 | MILD AND EFFICIENT PREPARATION METHOD FOR A-ACYLOXYENAMIDE COMPOUNDS AND USE THEREOF IN SYNTHESIS OF AMIDE AND POLYPEPTIDE | ANPEP, DNPEP, NAAA | NPC1 4621/4885RAB9A 1351/4885PYGL 1514/4885 |
| US-20220144793-A1 | WATER-SOLUBLE YNAMIDE COUPLING REAGENT AND PREPARATION METHOD AND USE THEREOF | SRMS, SYK, SRM | NPC1 4628/4885RAB9A 2557/4885PYGL 142/4885 |
| US-10836707-B2 | Mild and efficient preparation method for α-acyloxyenamide compounds and use thereof in synthesis of amide and polypeptide | ANPEP, DNPEP, PTMA | NPC1 4547/4885RAB9A 1384/4885PYGL 1623/4885 |
| US-20200299226-A1 | MILD AND EFFICIENT PREPARATION METHOD FOR A-ACYLOXYENAMIDE COMPOUNDS AND USE THEREOF IN SYNTHESIS OF AMIDE AND POLYPEPTIDE | ANPEP, DNPEP, NAAA | NPC1 4621/4885RAB9A 1351/4885PYGL 1514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.