Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | RET | P07949 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.49 |
| ▸ | HRH1 | P35367 | 6/20 | 0.49 |
| ▸ | HTR2B | P41595 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | HTR2C | P28335 | 4/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653565 | 0.89 | CYP3A4 (0.63) | CYP3A4CYP1A2RETCYP2C19CHRM1 | |
| SCHEMBL2878604 | 0.87 | BCHE (0.44) | CYP3A4CYP1A2RETCYP2C19CHRM1 | |
| SCHEMBL2858563 | 0.87 | BCHE (0.44) | CYP3A4CYP1A2RETCYP2C19CHRM1 | |
| SCHEMBL7815467 | 0.81 | CYP1A2 (0.41) | CYP3A4CYP1A2RETCYP2C19CHRM1 | |
| SCHEMBL15908345 | 0.81 | CHRM1 (0.49) | CYP3A4CYP1A2RETCYP2C19CHRM1 | |
| SCHEMBL652162 | 0.80 | HTR2B (0.68) | CYP1A2CHRM1SLC6A2HRH1HTR2B | |
| SCHEMBL652161 | 0.80 | HTR2B (0.68) | CYP1A2CHRM1SLC6A2HRH1HTR2B | |
| SCHEMBL13051513 | 0.80 | HTR2B (0.68) | CYP1A2CHRM1SLC6A2HRH1HTR2B | |
| SCHEMBL6970125 | 0.79 | ALDH1A1 (0.71) | CYP3A4CYP1A2RETCYP2C19CHRM1 | |
| SCHEMBL655611 | 0.79 | ALDH1A1 (0.71) | CYP3A4CYP1A2RETCYP2C19CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9540358-B2 | Tricyclic compounds as anticancer agents | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2017-01-10 | — | — | US | disclosed |
| US-20140213578-A1 | TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS | MT. SINAI SCHOOL OF MEDICINE (US) | 2014-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213578-A1 | TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS | TFEB, FOXO3, FOXO1 | CYP3A4 1910/4885CYP1A2 2436/4885RET 2318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.