SCHEMBL15920162

SCHEMBL15920162

N#Cc1ccc(NC(=O)N2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 2/20 0.60
NAMPT P43490 4/20 0.59
PANK3 Q9H999 2/20 0.58
CACNA2D1 P54289 2/20 0.56
CACNA1B Q00975 2/20 0.56
CACNB1 Q02641 2/20 0.56
CACNA1C Q13936 1/20 0.56
OPRD1 P41143 2/20 0.54
MGLL Q99685 2/20 0.54
OPRM1 P35372 1/20 0.52
OPRK1 P41145 1/20 0.52
OPRL1 P41146 1/20 0.52
KMT2A Q03164 2/20 0.51
CNR1 P21554 2/20 0.51
CNR2 P34972 2/20 0.51
HTT P42858 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
MEN1 O00255 1/20 0.50
GOT1 P17174 1/20 0.50
MAOB P27338 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15920165 0.87 CACNA2D1 (0.68) FAAHCACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL19357237 0.85 NPY2R (0.66) OPRD1MGLLOPRM1OPRK1OPRL1
SCHEMBL15920269 0.84 CA12 (0.64) CACNA2D1CACNA1BCACNB1CACNA1CMGLL
SCHEMBL15920168 0.83 CACNA2D1 (0.61) FAAHNAMPTCACNA2D1CACNA1BCACNB1
SCHEMBL19231616 0.82 PANK3 (0.66) FAAHNAMPTPANK3MGLLHTT
SCHEMBL14434233 0.81 PANK3 (0.72) FAAHNAMPTPANK3KMT2AHTT
SCHEMBL15919857 0.80 MAPT (0.70) FAAHCACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL15920163 0.80 NPY2R (0.76) FAAHCACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL15920167 0.78 FAAH (0.64) FAAHCACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL28363514 0.78 NAMPT (0.66) FAAHNAMPTPANK3KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014116684-A1 NON-PEPTIDIC NEUROPEPTIDE Y RECEPTOR MODULATORS ROBERTS EDWARD (US) 2014-07-31 WO disclosed