SCHEMBL15923005

SCHEMBL15923005

c1ccc2c(NCCN3CCOCC3)ccnc2c1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 6/20 0.76
LMNA P02545 2/20 0.74
POLB P06746 2/20 0.74
KMT2A Q03164 2/20 0.74
MEN1 O00255 1/20 0.74
MITF O75030 1/20 0.74
HPGD P15428 1/20 0.74
SMARCA2 P51531 1/20 0.74
L3MBTL1 Q9Y468 1/20 0.74
ACP1 P24666 2/20 0.63
HTR1A P08908 2/20 0.61
ADRA1D P25100 2/20 0.61
ADRA1A P35348 2/20 0.61
ADRA1B P35368 2/20 0.61
TOP2A P11388 1/20 0.56
FERMT2 Q96AC1 1/20 0.56
KDM4E B2RXH2 1/20 0.53
NPC1 O15118 1/20 0.53
GLA P06280 1/20 0.53
GAA P10253 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19563520 0.86 HRH3 (1.00) HRH3SMARCA2ACP1HTR1AADRA1D
SCHEMBL28308865 0.78 HRH3 (0.80) HRH3SMARCA2ACP1HTR1AADRA1D
SCHEMBL28227463 0.78 CNR1 (0.59) HRH3LMNAPOLBKMT2AMEN1
SCHEMBL11604511 0.78 KDM4E (0.67) LMNAPOLBKMT2AMEN1MITF
SCHEMBL30457841 0.78 ACP1 (1.00) LMNAKMT2AMEN1SMARCA2ACP1
SCHEMBL17651549 0.78 ACP1 (1.00) LMNAKMT2AMEN1SMARCA2ACP1
SCHEMBL491645 0.77 HRH3 (1.00) HRH3HTR1AADRA1DADRA1AADRA1B
SCHEMBL10129706 0.76 KMT2A (0.53) LMNAPOLBKMT2AMEN1MITF
SCHEMBL18095970 0.75 HTR1A (0.80) HRH3HTR1AADRA1DADRA1AADRA1B
SCHEMBL31428721 0.75 ALDH1A1 (0.69) LMNAKMT2AMEN1HPGDL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250034139-A1 AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC, AND ANTICANCER ACTIVITY PHARMA CINQ, LLC 2025-01-30 US disclosed
US-12139483-B2 Imidazoquinolyl compounds having anti-inflammatory, antifungal, antiparasitic, and anticancer activity PHARMA CINQ, LLC (US) 2024-11-12 US disclosed
US-20210163476-A1 IMIDAZOQUINOLYL COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC, AND ANTICANCER ACTIVITY PHARMA CINQ, LLC 2021-06-03 US disclosed
EP-3807248-A1 BICYCLE TOPOISOMERASE I INHIBITING COMPOUNDS, PROCESS FOR PREPARATION AND USE THEREOF Council of Scientific and Industrial Research (IN) 2021-04-21 EP disclosed
US-10934284-B2 Aminoquinazoline compounds having anti-inflammatory, antifungal, antiparasitic, and anticancer activity WELLSTAT THERAPEUTICS CORPORATION (US) 2021-03-02 US disclosed
EP-3632426-A1 AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC AND ANTICANCER ACTIVITY Wellstat Therapeutics Corporation (US) 2020-04-08 EP disclosed
EP-2950649-B1 AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC AND ANTICANCER ACTIVITY WELLSTAT THERAPEUTICS CORP (US) 2020-03-04 EP disclosed
US-20190194193-A1 AMINOQUINAZOLINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC, AND ANTICANCER ACTIVITY PHARMA CINQ, LLC 2019-06-27 US disclosed
US-20180298000-A1 AMINOQUINOLINE COMPOUNDS HAVING ANTICANCER ACTIVITY PHARMA CINQ, LLC 2018-10-18 US disclosed
US-10030015-B2 Amine compounds having anti-inflammatory, antifungal, antiparasitic, and anticancer activity WELLSTAT THERAPEUTICS CORPORATION (US) 2018-07-24 US disclosed
US-20150361077-A1 AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC, AND ANTICANCER ACTIVITY PHARMA CINQ, LLC 2015-12-17 US disclosed
EP-2950649-A2 AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC AND ANTICANCER ACTIVITY Wellstat Therapeutics Corporation (US) 2015-12-09 EP disclosed
WO-2014120995-A2 AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC AND ANTICANCER ACTIVITY WELLSTAT THERAPEUTICS CORPORATION (US) 2014-08-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210163476-A1 IMIDAZOQUINOLYL COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC, AND ANTICANCER ACTIVITY NOD1, NLRP3, AADAC HRH3 606/4885LMNA 3072/4885POLB 1625/4885
US-20180298000-A1 AMINOQUINOLINE COMPOUNDS HAVING ANTICANCER ACTIVITY MYC, AAAS, ASNS HRH3 284/4885LMNA 2294/4885POLB 1222/4885
US-20190194193-A1 AMINOQUINAZOLINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC, AND ANTICANCER ACTIVITY AAAS, AADAC, NFKBIA HRH3 263/4885LMNA 2707/4885POLB 1651/4885
US-20250034139-A1 AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC, AND ANTICANCER ACTIVITY AADAC, CASP1, AAAS HRH3 93/4885LMNA 3068/4885POLB 1080/4885
US-10030015-B2 Amine compounds having anti-inflammatory, antifungal, antiparasitic, and anticancer activity AADAC, CASP1, AAAS HRH3 93/4885LMNA 3068/4885POLB 1080/4885
US-20150361077-A1 AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC, AND ANTICANCER ACTIVITY AADAC, CASP1, AAAS HRH3 93/4885LMNA 3068/4885POLB 1080/4885
US-12139483-B2 Imidazoquinolyl compounds having anti-inflammatory, antifungal, antiparasitic, and anticancer activity NOD1, NLRP3, AADAC HRH3 606/4885LMNA 3072/4885POLB 1625/4885
US-10934284-B2 Aminoquinazoline compounds having anti-inflammatory, antifungal, antiparasitic, and anticancer activity AAAS, AADAC, NFKBIA HRH3 263/4885LMNA 2707/4885POLB 1651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.