Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637934 | 1.00 | MGAM (0.39) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL261461 | 1.00 | MGAM (0.39) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL4381196 | 0.92 | MGAM (0.35) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL4375315 | 0.92 | MGAM (0.35) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL4390957 | 0.92 | MGAM (0.35) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL15030939 | 0.87 | GAA (0.46) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL28247872 | 0.86 | TAS1R3 (0.33) | ALDH1A1HSD17B10POLBKDM4E | |
| SCHEMBL4386597 | 0.86 | GAA (0.36) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL4392181 | 0.86 | GAA (0.36) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL4385798 | 0.86 | GAA (0.36) | MGAMGAASIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119776295-A | Olefin reductase, coding gene, vector, engineering bacteria and application thereof | 浙江工业大学 | 2025-04-08 | — | — | CN | claimed |
| WO-2011141923-A2 | IMPROVED SYNTHESIS OF OPTICALLY PURE (S) - 3-CYANO-5-METHYL-HEXANOIC ACID ALKYL ESTER, AN INTERMEDIATE OF (S)- PREGABALIN | LUPIN LIMITED (IN) | 2011-11-17 | — | — | WO | claimed |
| CN-119776295-A | Olefin reductase, coding gene, vector, engineering bacteria and application thereof | 浙江工业大学 | 2025-04-08 | — | — | CN | disclosed |
| CN-116041214-A | Preparation method and application of pregabalin intermediate | 奥锐特药业股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| WO-2021105742-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF PREGABALIN | HIKAL LIMITED (IN) | 2021-06-03 | — | — | WO | disclosed |
| CN-108715881-B | Method for regioselective and stereoselective biocatalytic synthesis of pregabalin chiral intermediate | 浙江工业大学 | 2020-11-10 | — | — | CN | disclosed |
| WO-2020183376-A1 | GREENER AND ECONOMIC PROCESS FOR PREPARATION OF PREGABALIN | HIKAL LIMITED (IN) | 2020-09-17 | — | — | WO | disclosed |
| CN-111333529-A | Preparation method of pregabalin | 北京万全德众医药生物技术有限公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-106676084-B | A kind of lipase mutant, encoding gene and its application from thermophilic ankle section bacterium | 浙江工业大学 | 2019-11-29 | — | — | CN | disclosed |
| CN-106591258-B | A kind of lipase gene, carrier, engineering bacteria and its application | 新余学院 | 2019-06-04 | — | — | CN | disclosed |
| EP-2916832-B1 | A PROCESS FOR THE PREPARATION OF PREGABALIN | HIKAL LTD (IN) | 2019-01-16 | — | — | EP | disclosed |
| WO-2006000904-A2 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-05 | — | — | WO | disclosed |
| US-20050283023-A1 | Preparation of pregabalin and related compounds | HU SHANGHUI | 2005-12-22 | — | — | US | disclosed |
| US-6891059-B2 | Asymmetric synthesis of pregabalin | WARNER-LAMBERT COMPANY (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1250311-B1 | ASYMMETRIC SYNTHESIS OF PREGABALIN | WARNER LAMBERT CO (US) | 2004-03-17 | — | — | EP | disclosed |
| US-20030212290-A1 | Asymmetric synthesis of pregabalin | BURK MARK JOSEPH (US) | 2003-11-13 | — | — | US | disclosed |
| EP-1250311-A1 | ASYMMETRIC SYNTHESIS OF PREGABALIN | WARNER-LAMBERT COMPANY (US) | 2002-10-23 | — | — | EP | disclosed |
| US-20010016665-A1 | METHOD OF MAKING (S)-3-(AMINOMETHYL) -5- METHYLHEXANOIC ACID | GROTE TODD MICHEL (US) | 2001-08-23 | — | — | US | disclosed |
| WO-2001055090-A1 | ASYMMETRIC SYNTHESIS OF PREGABALIN | WARNER-LAMBERT COMPANY (US) | 2001-08-02 | — | — | WO | disclosed |
| US-5840956-A | Method of making (S)-3-(Aminomethyl)-5-Methylhexanoic acid | WARNER-LAMBERT COMPANY (US) | 1998-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212290-A1 | Asymmetric synthesis of pregabalin | GABRA5, GABRA6, GABRE | MGAM 1223/4885GAA 3133/4885SI 1615/4885 |
| US-20010016665-A1 | METHOD OF MAKING (S)-3-(AMINOMETHYL) -5- METHYLHEXANOIC ACID | APEH, CA6, ALKBH3 | MGAM 280/4885GAA 975/4885SI 56/4885 |
| US-20050283023-A1 | Preparation of pregabalin and related compounds | GABRE, GABRG1, GABRA6 | MGAM 136/4885GAA 151/4885SI 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.