Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15939985 | 0.87 | HSD17B10 (0.70) | HSD17B10ALDH1A1MAPTMAPK1TSHR | |
| SCHEMBL15940088 | 0.86 | MAPT (0.67) | HSD17B10ALDH1A1MAPTMAPK1TSHR | |
| SCHEMBL1883906 | 0.81 | ALDH1A1 (0.66) | HSD17B10ALDH1A1MAPTMAPK1TSHR | |
| SCHEMBL24128292 | 0.80 | ALDH1A1 (0.51) | HSD17B10ALDH1A1MAPTMAPK1TSHR | |
| SCHEMBL15939770 | 0.80 | KDM4E (0.53) | HSD17B10ALDH1A1MAPTMAPK1TSHR | |
| SCHEMBL15940127 | 0.79 | ALDH1A1 (0.74) | HSD17B10ALDH1A1MAPTMAPK1LMNA | |
| SCHEMBL14975744 | 0.79 | PRKCZ (0.68) | HSD17B10ALDH1A1MAPTMAPK1TSHR | |
| SCHEMBL15940251 | 0.79 | IKBKB (0.56) | HSD17B10ALDH1A1MAPTMAPK1TSHR | |
| SCHEMBL15940253 | 0.79 | KDM4E (0.56) | HSD17B10ALDH1A1MAPTMAPK1TSHR | |
| SCHEMBL15940360 | 0.78 | ALDH1A1 (0.70) | HSD17B10ALDH1A1MAPTMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276489-A1 | Inhibitors of Tubulin Polymerization | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | disclosed |
| US-7071190-B2 | Inhibitors to tubulin polymerization | RIGEL PHARMACEUTICALS, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| US-20030225112-A1 | Inhibitors to tubulin polymerization | RIGEL PHARMACEUTICALS, INC. | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225112-A1 | Inhibitors to tubulin polymerization | TUBB3, TUBB1, TUBB | HSD17B10 2536/4885ALDH1A1 2477/4885MAPT 26/4885 |
| US-20060276489-A1 | Inhibitors of Tubulin Polymerization | TUBB3, TUBB1, TUBB | HSD17B10 2485/4885ALDH1A1 2377/4885MAPT 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.