Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | POLA1 | P09884 | 1/20 | 0.76 |
| ▸ | POLD1 | P28340 | 1/20 | 0.76 |
| ▸ | TK1 | P04183 | 5/20 | 0.65 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.53 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALB | P02768 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | DTYMK | P23919 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18923744 | 1.00 | POLB (0.76) | POLBPOLA1POLD1TK1P2RY2 | |
| SCHEMBL17225234 | 1.00 | POLB (0.76) | POLBPOLA1POLD1TK1P2RY2 | |
| SCHEMBL23405862 | 1.00 | POLB (0.76) | POLBPOLA1POLD1TK1P2RY2 | |
| SCHEMBL24058347 | 1.00 | POLB (0.76) | POLBPOLA1POLD1TK1P2RY2 | |
| SCHEMBL17227489 | 0.95 | POLB (0.69) | POLBPOLA1POLD1TK1LMNA | |
| SCHEMBL22186553 | 0.91 | TK1 (0.77) | POLBPOLA1POLD1TK1LMNA | |
| SCHEMBL21579405 | 0.90 | POLB (0.71) | POLBPOLA1POLD1TK1DTYMK | |
| SCHEMBL17225231 | 0.90 | POLB (0.62) | POLBPOLA1POLD1TK1LMNA | |
| SCHEMBL7193310 | 0.90 | POLB (0.76) | POLBPOLA1POLD1TK1P2RY2 | |
| SCHEMBL27102380 | 0.90 | POLB (0.64) | POLBPOLA1POLD1TK1P2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220396818-A1 | POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM | OXFORD NANOPORE TECHNOLOGIES PLC (GB) | 2022-12-15 | — | — | US | disclosed |
| US-20220177937-A1 | POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM | OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) | 2022-06-09 | — | — | US | disclosed |
| US-20220177938-A1 | POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM | OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) | 2022-06-09 | — | — | US | disclosed |
| US-20220112552-A1 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2022-04-14 | — | — | US | disclosed |
| US-11208691-B2 | Synthesis of cleavable fluorescent nucleotides as reversible terminators for DNA sequencing by synthesis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-12-28 | — | — | US | disclosed |
| US-20210388432-A1 | POLYNUCLEOTIDE SYNTHESIS METHOD, KIT AND SYSTEM | OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) | 2021-12-16 | — | — | US | disclosed |
| US-11180522-B2 | Disulfide-linked reversible terminators | CENTRILLION TECHNOLOGY HOLDINGS CORPORATION (KY) | 2021-11-23 | — | — | US | disclosed |
| US-20210324436-A1 | METHODS AND REAGENTS FOR SYNTHESISING POLYNUCLEOTIDE MOLECULES | OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) | 2021-10-21 | — | — | US | disclosed |
| US-20210198710-A1 | POLYNUCLEOTIDE SYNTHESIS METHOD, SYSTEM AND KIT | OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) | 2021-07-01 | — | — | US | disclosed |
| US-20190085388-A1 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-21 | — | — | US | disclosed |
| US-20170321267-A1 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-11-09 | — | — | US | disclosed |
| EP-2964612-B1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LTD (GB) | 2017-02-01 | — | — | EP | disclosed |
| EP-2964612-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | Illumina Cambridge Limited (GB) | 2016-01-13 | — | — | EP | disclosed |
| US-9156987-B2 | Polymethine compounds and their use as fluorescent labels | ILLUMINA CAMBRIDGE LIMITED (GB) | 2015-10-13 | — | — | US | disclosed |
| US-20150167073-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2015-06-18 | — | — | US | disclosed |
| US-8993784-B2 | Polymethine compounds and their use as fluorescent labels | ILLUMINA CAMBRIDGE LIMITED (GB) | 2015-03-31 | — | — | US | disclosed |
| US-20140322713-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2014-10-30 | — | — | US | disclosed |
| WO-2014135221-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LTD (GB) | 2014-09-12 | — | — | WO | disclosed |
| US-20140255917-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2014-09-11 | — | — | US | disclosed |
| US-8809551-B1 | Polymethine compounds and their use as fluorescent labels | ILLUMINA CAMBRIDGE LIMITED (GB) | 2014-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112552-A1 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | RNGTT, TYMS, DUT | POLB 20/4885POLA1 121/4885POLD1 392/4885 |
| US-20140322713-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | POLRMT, FBL, POLM | POLB 15/4885POLA1 171/4885POLD1 153/4885 |
| US-11208691-B2 | Synthesis of cleavable fluorescent nucleotides as reversible terminators for DNA sequencing by synthesis | TYMS, DUT, DNTT | POLB 26/4885POLA1 116/4885POLD1 366/4885 |
| US-20170321267-A1 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | RNGTT, TYMS, DUT | POLB 20/4885POLA1 121/4885POLD1 392/4885 |
| US-20190085388-A1 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS | RNGTT, TYMS, DUT | POLB 20/4885POLA1 121/4885POLD1 392/4885 |
| US-11180522-B2 | Disulfide-linked reversible terminators | RNGTT, NSUN3, NSUN2 | POLB 32/4885POLA1 165/4885POLD1 216/4885 |
| US-20150167073-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | POLRMT, FBL, POLM | POLB 15/4885POLA1 171/4885POLD1 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.