Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | FEN1 | P39748 | 3/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | MPL | P40238 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15948359 | 0.80 | KDM4E (0.39) | KDM4EHSD17B10ATRCYP11B2ADORA2A | |
| SCHEMBL3128136 | 0.77 | ATR (0.48) | ATRADORA2AADORA1ALOX5APFEN1 | |
| SCHEMBL3395736 | 0.72 | ADORA2A (0.50) | KDM4EHSD17B10ATRADORA2AADORA1 | |
| SCHEMBL2325695 | 0.71 | ADORA2A (0.67) | KDM4EHSD17B10ADORA2AADORA1ADORA3 | |
| SCHEMBL31009002 | 0.71 | ADORA2A (0.67) | KDM4EHSD17B10ADORA2AADORA1ADORA3 | |
| SCHEMBL3395686 | 0.69 | HSD17B1 (0.40) | KDM4EHSD17B10ATRADORA2AADORA1 | |
| SCHEMBL2324805 | 0.69 | MPL (0.50) | KDM4EATRADORA2AADORA1ALOX5AP | |
| SCHEMBL31018102 | 0.69 | MPL (0.50) | KDM4EATRADORA2AADORA1ALOX5AP | |
| SCHEMBL3399237 | 0.68 | ADORA2A (0.68) | KDM4EHSD17B10ADORA2AADORA1L3MBTL1 | |
| SCHEMBL3396593 | 0.67 | KDM4E (0.45) | KDM4EADORA2AADORA1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809525-B2 | 1,2,4-triazine-4-amine derivatives | HEPTARES THERAPEUTICS LIMITED (GB) | 2014-08-19 | — | — | US | disclosed |