Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 5/20 | 0.51 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL910557 | 0.88 | RXRA (0.55) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL911815 | 0.85 | MGLL (0.47) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL15949260 | 0.85 | MGLL (0.67) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL14878216 | 0.84 | MGLL (0.46) | KDM4EALDH1A1POLBMGLLL3MBTL3 | |
| SCHEMBL693780 | 0.84 | KMT2A (0.56) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL15949350 | 0.83 | KDM4E (0.60) | TP53KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL15949299 | 0.83 | ALDH1A1 (0.64) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL698353 | 0.81 | MGLL (0.59) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL911712 | 0.81 | MGLL (0.54) | KDM4EALDH1A1POLBMGLLL3MBTL3 | |
| SCHEMBL913079 | 0.81 | L3MBTL3 (0.56) | KDM4EALDH1A1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |