Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 5/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 3/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | KIF20A | O95235 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15956137 | 0.91 | IMPDH2 (0.52) | HTR1DTRPM8KDM4EMAPTLTA4H | |
| SCHEMBL7085697 | 0.83 | TRPM8 (0.60) | HTR1DTRPM8KDM4EMAPTLTA4H | |
| SCHEMBL19234918 | 0.81 | TRPM8 (0.57) | HTR1DTRPM8KDM4EMAPTLTA4H | |
| SCHEMBL38657787 | 0.79 | HTR1D (0.61) | HTR1DTRPM8KDM4EMAPTLTA4H | |
| SCHEMBL5260125 | 0.77 | HTR1D (0.58) | HTR1DTRPM8KDM4EMAPTLTA4H | |
| SCHEMBL28273019 | 0.77 | TRPM8 (0.58) | HTR1DTRPM8KDM4EMAPTLTA4H | |
| SCHEMBL11266559 | 0.77 | TRPM8 (0.65) | HTR1DTRPM8KDM4EMAPTLTA4H | |
| SCHEMBL27370044 | 0.76 | TRPM8 (0.52) | HTR1DTRPM8KDM4EMAPTLTA4H | |
| SCHEMBL8845884 | 0.76 | HTR1D (0.49) | HTR1DTRPM8KDM4EMAPTLTA4H | |
| SCHEMBL15955987 | 0.76 | TRPM8 (0.70) | HTR1DTRPM8KDM4EMAPTLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956450-B1 | HYDROXYINDALPINE DERIVATIVES AND THEIR MEDICAL USE | UNIV MUENCHEN TECH (DE) | 2018-07-25 | — | — | EP | disclosed |
| US-9637471-B2 | Hydroxyindalpine derivatives and their medical use | TECHNISCHE UNIVERSITAT MUNCHEN (DE) | 2017-05-02 | — | — | US | disclosed |
| US-20150376164-A1 | HYDROXYINDALPINE DERIVATIVES AND THEIR MEDICAL USE | TECHNISCHE UNIVERSITAT MUNCHEN (DE) | 2015-12-31 | — | — | US | disclosed |
| EP-2956450-A1 | HYDROXYINDALPINE DERIVATIVES AND THEIR MEDICAL USE | Technische Universität München (DE) | 2015-12-23 | — | — | EP | disclosed |
| WO-2014125084-A1 | HYDROXYINDALPINE DERIVATIVES AND THEIR MEDICAL USE | Technische Universität München (DE) | 2014-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376164-A1 | HYDROXYINDALPINE DERIVATIVES AND THEIR MEDICAL USE | HTR5A, HTR4, HTR6 | HTR1D 15/4885TRPM8 1064/4885KDM4E 2655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.