Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | G6PD | P11413 | 1/20 | 0.60 |
| ▸ | CASP7 | P55210 | 1/20 | 0.60 |
| ▸ | CASP6 | P55212 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10970621 | 0.88 | HSP90AB1 (0.44) | G6PDCASP7CASP6KDM4EHIF1A | |
| SCHEMBL9632452 | 0.82 | ALDH1A1 (0.46) | G6PDCASP7CASP6KDM4EHIF1A | |
| SCHEMBL9058909 | 0.81 | GABRA1 (0.43) | KDM4EHIF1ATDP1HSP90AB1ALDH1A1 | |
| SCHEMBL7547028 | 0.81 | CD44 (0.43) | G6PDCASP7CASP6KDM4EHIF1A | |
| SCHEMBL8691817 | 0.81 | PARP1 (0.42) | G6PDCASP7CASP6KDM4EHIF1A | |
| SCHEMBL27355845 | 0.81 | G6PD (0.60) | G6PDCASP7CASP6KDM4EHIF1A | |
| SCHEMBL14255774 | 0.80 | KDM4E (0.67) | G6PDCASP7CASP6KDM4EHIF1A | |
| SCHEMBL17653405 | 0.80 | CTSD (0.49) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL1606580 | 0.80 | HSP90AB1 (0.55) | TDP1HSP90AB1MAPTALDH1A1HPGD | |
| SCHEMBL15153940 | 0.80 | HTT (0.64) | G6PDCASP7CASP6KDM4EHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102838505-B | Amides, its preparation method and application | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2016-02-17 | — | — | CN | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |
| CN-102838505-A | Amide compound and preparation method as well as application thereof | SHANGHAI INST PHARM INDUSTRY | 2012-12-26 | — | — | CN | disclosed |