Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 10/20 | 0.59 |
| ▸ | DRD2 | P14416 | 9/20 | 0.59 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763421 | 0.85 | KCNA5 (0.70) | DRD3DRD2NAMPTKCNA5 | |
| SCHEMBL19145557 | 0.83 | DRD3 (0.61) | DRD3DRD2NAMPTKCNA5 | |
| SCHEMBL16358258 | 0.83 | DRD3 (0.61) | DRD3DRD2NAMPTKCNA5MEN1 | |
| SCHEMBL4381167 | 0.82 | GPR183 (0.53) | DRD2MEN1KMT2A | |
| SCHEMBL25442213 | 0.81 | ALDH1A1 (0.71) | DRD3DRD2NAMPTKCNA5MEN1 | |
| SCHEMBL17886738 | 0.81 | HPGD (0.65) | DRD3DRD2NAMPTKCNA5MEN1 | |
| SCHEMBL6363456 | 0.81 | LSS (0.47) | DRD3DRD2KCNA5MEN1KMT2A | |
| SCHEMBL2222735 | 0.81 | DRD3 (0.58) | DRD3DRD2NAMPTKCNA5 | |
| SCHEMBL16627284 | 0.80 | KCNA5 (0.68) | DRD3DRD2NAMPTKCNA5MEN1 | |
| SCHEMBL6566902 | 0.80 | PLA2G2A (0.57) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919517-B2 | Indazole derivatives | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-04-05 | — | — | US | disclosed |
| US-20090082348-A1 | INDAZOLE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-03-26 | — | — | US | disclosed |
| US-7470717-B2 | Indazole derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-12-30 | — | — | US | disclosed |
| CN-100390149-C | Indazole derivatives | KYOWA HAKKO KOGYO KK (JP) | 2008-05-28 | — | — | CN | disclosed |
| US-20070117856-A1 | Indazole derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-05-24 | — | — | US | disclosed |
| CN-1777590-A | Indazole derivatives | KYOWA HAKKO KOGYO KK (JP) | 2006-05-24 | — | — | CN | disclosed |
| EP-1652842-A1 | INDAZOLE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |
| US-20050267133-A1 | Pyrazolopyrimidines as kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2005-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117856-A1 | Indazole derivatives | IGF1R, NR0B2, ADRA2B | DRD3 189/4885DRD2 269/4885NAMPT 3209/4885 |
| US-20050267133-A1 | Pyrazolopyrimidines as kinase inhibitors | BRAF, MAP3K2, MAP3K19 | DRD3 4612/4885DRD2 4691/4885NAMPT 848/4885 |
| US-20090082348-A1 | INDAZOLE DERIVATIVES | IGF1R, NR0B2, ADRA2B | DRD3 189/4885DRD2 269/4885NAMPT 3209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.