Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 7/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | FPR3 | P25089 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711122 | 0.93 | EPHX1 (0.45) | CACNA1IKCNH2FPR3FPR2EPHX1 | |
| SCHEMBL5505986 | 0.80 | SIGMAR1 (0.47) | FPR3FPR2ALDH1A1 | |
| SCHEMBL708612 | 0.78 | FPR3 (0.41) | CYP2C19TDP1FPR3FPR2EPHX1 | |
| SCHEMBL711457 | 0.77 | FPR3 (0.39) | KCNH2FPR3FPR2CACNA1HCACNA1G | |
| SCHEMBL15967368 | 0.76 | CACNA1H (0.35) | CACNA1H | |
| SCHEMBL710574 | 0.76 | GNAI3 (0.43) | FPR3FPR2EPHX1 | |
| SCHEMBL711901 | 0.74 | EPHX1 (0.51) | CYP2C19TDP1FPR3FPR2EPHX1 | |
| SCHEMBL15967264 | 0.73 | — | — | |
| SCHEMBL711160 | 0.71 | EPHX1 (0.51) | FPR3FPR2EPHX1CTSLCTSB | |
| SCHEMBL708362 | 0.70 | EPHX1 (0.54) | FPR3FPR2EPHX1CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |