SCHEMBL15977378

SCHEMBL15977378

C=C1C=C(C)C(=O)N1CC(C)C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EP300 Q09472 2/20 0.35
MPO P05164 1/20 0.35
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
ALDH1A1 P00352 8/20 0.33
RAB9A P51151 4/20 0.33
L3MBTL1 Q9Y468 3/20 0.33
NPC1 O15118 3/20 0.33
GAA P10253 3/20 0.33
RGS4 P49798 1/20 0.33
RGS8 P57771 1/20 0.33
TOP2A P11388 1/20 0.33
TDP1 Q9NUW8 2/20 0.32
TSHR P16473 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HSD17B10 Q99714 1/20 0.32
LMNA P02545 1/20 0.31
MAPK1 P28482 1/20 0.31
MAPT P10636 2/20 0.31
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7755344 0.82 EP300 (0.36) EP300MPOMEN1KMT2AALDH1A1
SCHEMBL18212514 0.79 ALDH1A1 (0.39) MEN1KMT2AALDH1A1RAB9AL3MBTL1
SCHEMBL19478665 0.71 MGLL (0.50) ALDH1A1TSHRSMN1; SMN2HSD17B10KDM4E
SCHEMBL15977327 0.69 ALDH1A1 (0.41) EP300MPOMEN1KMT2AALDH1A1
SCHEMBL23665440 0.67 EP300 (0.40) EP300MPOMEN1KMT2AALDH1A1
SCHEMBL14868092 0.67 MGLL (0.44) EP300MPOALDH1A1RAB9AL3MBTL1
SCHEMBL4482770 0.67 ALDH1A1 (0.53) MEN1KMT2AALDH1A1RAB9AL3MBTL1
SCHEMBL19301853 0.67 PTGS1 (0.36)
SCHEMBL8283005 0.65 ALDH1A1 (0.38) EP300MPOMEN1KMT2AALDH1A1
SCHEMBL8283004 0.65 ALDH1A1 (0.39) EP300MPOMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170247725-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-08-31 US disclosed
US-9493799-B2 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-11-15 US disclosed
US-20160032330-A1 P-450-CATALYZED ENANTIOSELECTIVE CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-02-04 US disclosed
US-20160002682-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES UNITED STATES DEPARTMENT OF ENERGY 2016-01-07 US disclosed
US-8993262-B2 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2015-03-31 US disclosed
US-20140242647-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2014-08-28 US disclosed