Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24499182 | 0.81 | ALDH1A1 (0.43) | ALDH1A1TSHRMEN1KMT2AMAPT | |
| SCHEMBL9023932 | 0.81 | ALDH1A1 (0.53) | ALDH1A1TSHRHSD17B1HSD17B2MEN1 | |
| SCHEMBL7291190 | 0.79 | ALDH1A1 (0.50) | ALDH1A1TSHRHSD17B1HSD17B2MEN1 | |
| SCHEMBL27775487 | 0.78 | NR3C1 (0.51) | ALDH1A1TSHRMEN1KMT2ANR3C1 | |
| SCHEMBL5409015 | 0.77 | ALDH1A1 (0.59) | ALDH1A1TSHRHSD17B1HSD17B2MEN1 | |
| SCHEMBL6774791 | 0.76 | BRD4 (0.55) | ALDH1A1TSHRADORA2AADORA2BMEN1 | |
| SCHEMBL11939269 | 0.75 | RXFP1 (0.49) | ALDH1A1TSHRHSD17B1HSD17B2MEN1 | |
| SCHEMBL31078153 | 0.75 | ALDH1A1 (0.59) | ALDH1A1TSHRADORA2AADORA2BADORA1 | |
| SCHEMBL29760424 | 0.75 | ALDH1A1 (0.59) | ALDH1A1TSHRHSD17B1HSD17B2ADORA2A | |
| SCHEMBL4796147 | 0.75 | ALDH1A1 (0.59) | ALDH1A1TSHRHSD17B1HSD17B2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133129-B2 | Bicyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-09-15 | — | — | US | disclosed |
| US-20140243310-A1 | BICYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243310-A1 | BICYCLIC COMPOUND | BICRA, NR3C2, CYP11B2 | ALDH1A1 450/4885TSHR 4134/4885HSD17B1 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.