Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.56 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29760424 | 1.00 | ALDH1A1 (0.59) | ALDH1A1HSD17B1HSD17B2MEN1KMT2A | |
| SCHEMBL31078153 | 0.86 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL10747417 | 0.85 | MAPT (0.56) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL24997149 | 0.83 | RORC (0.51) | ALDH1A1HSD17B1HSD17B2MAPTPKM | |
| SCHEMBL9400208 | 0.82 | HSD17B1 (0.77) | ALDH1A1HSD17B1HSD17B2MEN1KMT2A | |
| SCHEMBL17681670 | 0.82 | PYGL (0.48) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL24535027 | 0.82 | LMNA (0.48) | ALDH1A1KMT2AHTTCYP1A2CYP3A4 | |
| SCHEMBL29660685 | 0.82 | MAPT (0.50) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL23169455 | 0.81 | HTT (0.53) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL9971092 | 0.81 | TSHR (0.53) | ALDH1A1MEN1KMT2AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240132477-A1 | Benzimidazole Derivatives and Their Use As Inhibitors of ITK For The Treatment of Skin Disease | PFIZER INC. (US) | 2024-04-25 | — | — | US | disclosed |
| WO-2022130171-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS INHIBITORS OF ITK FOR THE TREATMENT OF SKIN DISEASE | PFIZER INC. (US) | 2022-06-23 | — | — | WO | disclosed |
| CN-113416139-B | 4-fluorine substituted aryl amine compound and synthetic method thereof | 江苏笃行致远新材料科技有限公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-113416139-A | 4-fluorine substituted aryl amine compound and synthetic method thereof | 江苏笃行致远新材料科技有限公司 | 2021-09-21 | — | — | CN | disclosed |
| WO-2018207120-A1 | A PROCESS FOR THE PREPARATION OF 4-FLUORO-2-METHOXY-5-NITROANILINE | AUROBINDO PHARMA LIMITED (IN) | 2018-11-15 | — | — | WO | disclosed |
| US-7381728-B2 | Piperazine derivatives useful for the treatment of gastrointestinal disorders | GLAXO GROUP LIMITED (GB) | 2008-06-03 | — | — | US | disclosed |
| US-20070259877-A1 | Piperazine Derivatives Useful for the Treatment of Gastrointestinal Disorders | GLAXO GROUP LIMITED | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240132477-A1 | Benzimidazole Derivatives and Their Use As Inhibitors of ITK For The Treatment of Skin Disease | ITK, BLK, BCKDK | ALDH1A1 412/4885HSD17B1 806/4885HSD17B2 1260/4885 |
| US-20070259877-A1 | Piperazine Derivatives Useful for the Treatment of Gastrointestinal Disorders | GHSR, GHRHR, GIPR | ALDH1A1 2084/4885HSD17B1 614/4885HSD17B2 443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.