Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 1/20 | 0.44 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004256 | 0.86 | L3MBTL1 (0.42) | L3MBTL1MEN1KMT2ARORCGPR142 | |
| SCHEMBL16004010 | 0.82 | PKM (0.55) | MEN1KMT2AALDH1A1 | |
| SCHEMBL16004016 | 0.81 | PKM (0.43) | L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL16004161 | 0.80 | MAPK1 (0.47) | MEN1KMT2AMAPK1GPR142ALDH1A1 | |
| SCHEMBL16004328 | 0.80 | ALDH1A1 (0.43) | EPHX2L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL16004098 | 0.79 | PKM (0.50) | L3MBTL1MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL16004259 | 0.79 | TSHR (0.49) | NPSR1MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL16004231 | 0.78 | PKM (0.53) | NPSR1MEN1KMT2ARORCALDH1A1 | |
| SCHEMBL16004337 | 0.78 | LMNA (0.51) | MEN1KMT2AALDH1A1 | |
| SCHEMBL16004230 | 0.77 | PKM (0.46) | L3MBTL1NPSR1RORCMAPK1GPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |