Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | USP2 | O75604 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | STIM1 | Q13586 | 3/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.42 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14887577 | 0.89 | HSD17B10 (0.55) | HSD17B10ALDH1A1USP2POLBSMN1; SMN2 | |
| SCHEMBL16017262 | 0.88 | GAA (0.48) | HSD17B10ALDH1A1USP2POLBSMN1; SMN2 | |
| SCHEMBL14881333 | 0.88 | STIM1 (0.50) | HSD17B10ALDH1A1USP2POLBSMN1; SMN2 | |
| SCHEMBL16019776 | 0.87 | ALDH1A1 (0.56) | HSD17B10ALDH1A1POLBSMN1; SMN2LMNA | |
| SCHEMBL14887335 | 0.87 | BACE1 (0.42) | ALDH1A1SMN1; SMN2MAPTSTIM1ORAI1 | |
| SCHEMBL16019798 | 0.83 | DGAT1 (0.46) | ALDH1A1STIM1ORAI1ORAI2IL2 | |
| SCHEMBL16017213 | 0.83 | GRM1 (0.48) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL14887591 | 0.82 | STIM1 (0.46) | HSD17B10ALDH1A1USP2POLBSMN1; SMN2 | |
| SCHEMBL16017203 | 0.82 | RAB9A (0.51) | ALDH1A1POLBSMN1; SMN2LMNAHTT | |
| SCHEMBL14887576 | 0.80 | SCN10A (0.44) | MAPTSTIM1ORAI1ORAI2IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | HSD17B10 3352/4885ALDH1A1 4409/4885USP2 3918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.