SCHEMBL160178

SCHEMBL160178

COC(=O)[C@@H](NC(=O)c1ccccc1)[C@@H](C)O

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.54
KMT2A Q03164 2/20 0.50
SLC1A2 P43004 1/20 0.50
TAS1R3 Q7RTX0 1/20 0.50
TAS1R1 Q7RTX1 1/20 0.50
LNPEP Q9UIQ6 1/20 0.50
CA2 P00918 2/20 0.49
CA1 P00915 1/20 0.49
ALDH1A1 P00352 2/20 0.48
PPARG P37231 1/20 0.48
PPARA Q07869 1/20 0.48
KDM4E B2RXH2 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.46
RAB9A P51151 1/20 0.46
HPGD P15428 1/20 0.46
CCR1 P32246 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5673253 1.00 GAA (0.54) GAAKMT2ASLC1A2TAS1R3TAS1R1
SCHEMBL225434 1.00 GAA (0.54) GAAKMT2ASLC1A2TAS1R3TAS1R1
SCHEMBL1109091 1.00 GAA (0.54) GAAKMT2ASLC1A2TAS1R3TAS1R1
SCHEMBL6231982 1.00 GAA (0.54) GAAKMT2ASLC1A2TAS1R3TAS1R1
SCHEMBL17283030 1.00 GAA (0.54) GAAKMT2ASLC1A2TAS1R3TAS1R1
SCHEMBL225433 1.00 GAA (0.54) GAAKMT2ASLC1A2TAS1R3TAS1R1
SCHEMBL403933 0.94 RAB9A (0.56) GAAKMT2ASLC1A2TAS1R3TAS1R1
SCHEMBL12837602 0.94 RAB9A (0.56) GAAKMT2ASLC1A2TAS1R3TAS1R1
SCHEMBL1109093 0.91 NPC1 (0.54) GAATAS1R3TAS1R1LNPEPCA2
SCHEMBL12055633 0.91 NPC1 (0.54) GAATAS1R3TAS1R1LNPEPCA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6306203-B1 FOR USE IN INK JET PRINTING, INCLUDING PIEZOELECTRIC INK JET PRINTING AND ACOUSTIC INK JET PRINTING XEROX CORPORATION 2001-10-23 US claimed
US-20250074887-A1 PHARMACEUTICAL COMPOSITIONS OF 6-(2-(2H-TETRAZOL-5-YL)ETHYL)DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AND DERIVATIVES THEREOF Sea Pharmaceuticals LLC. (US) 2025-03-06 US disclosed
US-20170349544-A1 Ethynylbenzene Derivatives DUKE UNIVERSITY 2017-12-07 US disclosed
US-20170349544-A1 Ethynylbenzene Derivatives DUKE UNIVERSITY 2017-12-07 US disclosed
US-20170313992-A1 KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT 2017-11-02 US disclosed
US-9738604-B2 Ethynylbenzene derivatives DUKE UNIVERSITY (US) 2017-08-22 US disclosed
US-9738604-B2 Ethynylbenzene derivatives DUKE UNIVERSITY (US) 2017-08-22 US disclosed
US-9719071-B2 Ketoreductase polypeptides for the production of azetidinone CODEXIS, INC. (US) 2017-08-01 US disclosed
US-20170121689-A1 KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT 2017-05-04 US disclosed
US-9580694-B2 Ketoreductase polypeptides for the production of azetidinone CODEXIS, INC. (US) 2017-02-28 US disclosed
US-20030064972-A1 Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis MPM ASSET MANAGEMENT INVESTORS 2002 BVIII LLC 2003-04-03 US disclosed
WO-2003024943-A2 ARYL DERIVATIVES FOR THE TREATMENT OF DIABETES, HYPERLIPIDEMIA, HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS ARYX THERAPEUTICS (US) 2003-03-27 WO disclosed
US-20030027798-A1 Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis MPM ASSET MANAGEMENT INVESTORS 2002 BVIII LLC 2003-02-06 US disclosed
EP-1276730-A2 THIAZOLIDINEDIONE ANALOGUES AND THEIR USE FOR THE TREATMENT OF DIABETES ARYx Therapeutics (US) 2003-01-22 EP disclosed
US-6498256-B2 CATALYSTS FOR ASYMMETRIC ADDITION REACTIONS, FOR EXAMPLE OF HYDROGEN, TO PROCHIRAL UNSATURATED ORGANIC COMPOUNDS. SOLVIAS AG (CH) 2002-12-24 US disclosed
US-20020128486-A1 Phosphinite-oxazolines and metal complexes PFALTZ ANDREAS (CH) 2002-09-12 US disclosed
US-20020062027-A1 Phosphinite-oxazolines and metal complexes SOLVIAS AG (CH) 2002-05-23 US disclosed
EP-1191030-A2 Phosphinite-oxazolines and metal complexes Solvias AG (CH) 2002-03-27 EP disclosed
WO-2001081328-A2 THIAZOLIDINEDIONE ANALOGUES AND THEIR USE FOR THE TREATMENT OF DIABETES ARYX THERAPEUTICS (US) 2001-11-01 WO disclosed
US-6306203-B1 FOR USE IN INK JET PRINTING, INCLUDING PIEZOELECTRIC INK JET PRINTING AND ACOUSTIC INK JET PRINTING XEROX CORPORATION 2001-10-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250074887-A1 PHARMACEUTICAL COMPOSITIONS OF 6-(2-(2H-TETRAZOL-5-YL)ETHYL)DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AND DERIVATIVES THEREOF GABRQ, GRIK5, CYP3A7 GAA 361/4885KMT2A 1192/4885SLC1A2 178/4885
US-20020062027-A1 Phosphinite-oxazolines and metal complexes OXER1, OXGR1, H1-4 GAA 4861/4885KMT2A 1894/4885SLC1A2 2286/4885
US-20030064972-A1 Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis LIPA, LIPC, CETP GAA 29/4885KMT2A 1895/4885SLC1A2 2160/4885
US-20020128486-A1 Phosphinite-oxazolines and metal complexes OXER1, OXGR1, H1-4 GAA 4861/4885KMT2A 1894/4885SLC1A2 2286/4885
US-20170349544-A1 Ethynylbenzene Derivatives Q6ZSR9, EPX, ZYX GAA 1139/4885KMT2A 2611/4885SLC1A2 4157/4885
US-20030027798-A1 Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis LIPA, LIPC, CETP GAA 29/4885KMT2A 1895/4885SLC1A2 2160/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.