GABRQ — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15406	0.61	20/20
Fipronil (SCHEMBL15088)	0.59	20/20
SCHEMBL41972	0.59	20/20
Fipronil (SCHEMBL44222)	0.59	20/20
Ethiprole (SCHEMBL27048)	0.56	20/20
SCHEMBL25897	0.51	20/20
SCHEMBL33214	0.52	19/20
SCHEMBL26584	0.51	19/20
SCHEMBL9107	0.56	12/20
SCHEMBL8532	1.00	11/20
Gedocarnil (SCHEMBL194687)	0.59	11/20
SCHEMBL9035	0.56	10/20
SCHEMBL8632	0.54	10/20
SCHEMBL8670	0.57	9/20
SCHEMBL8856	0.53	9/20
SCHEMBL9273	0.53	9/20
SCHEMBL8931	0.51	9/20
SCHEMBL8932	0.51	9/20
SCHEMBL9163	0.58	8/20
SCHEMBL8941	0.54	8/20

Clinical trials — most relevant to GABRQ by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Safety of Ramelteon in Elderly Subjects	PHASE4	COMPLETED
Computational Assessment of GABA Receptor Modulation in PTSD	PHASE4	RECRUITING
The Effects of Levetiracetam on Alcohol Dependent Subjects	PHASE4	COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia	PHASE3	COMPLETED
Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia	PHASE2/PHASE3	COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia	PHASE2	COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia	PHASE2	COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy	PHASE1/PHASE2	WITHDRAWN
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome	PHASE2	RECRUITING
Vigabatrin for Treatment of Cocaine Dependence	PHASE2	COMPLETED
Physiologic Effects of Topiramate on Cognition	PHASE1	COMPLETED
Neurosteroids and Acute Alcohol Intoxication in Humans	PHASE1	UNKNOWN
PET Imaging of Brain Peripheral Benzodiazepine Receptors	PHASE1	COMPLETED
MEG Study of Acute STX209 Effects in ASD	EARLY_PHASE1	COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T	EARLY_PHASE1	UNKNOWN
Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression	EARLY_PHASE1	RECRUITING
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy	nan	UNKNOWN
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
GABA Biomarkers in Dravet Syndrome	nan	RECRUITING
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle	nan	COMPLETED
Assessment of Peripheral GABA Receptors for Local Pain Relief	nan	UNKNOWN
GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression	nan	COMPLETED
Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk	nan	COMPLETED
Effect of Gabapentin on GABA Concentration and Emotional Processing	nan	COMPLETED
Mechanisms of Human Plasticity in the Human System	nan	COMPLETED
Functional Study of Inhibitory Neurotransmission in the Human Epileptic Brain.	nan	RECRUITING
Relationship of Nocturnal Concentrations of Melatonin, γ-aminobutyric Acid and Total Antioxidants With Insomnia	nan	UNKNOWN
Study of GABA-A Receptors in the Generation of Tics in Patients With Tourette's Syndrome	nan	COMPLETED
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory	nan	COMPLETED
Brain Changes in Patients With Focal Hand Dystonia	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GABRQ binder may also engage these)

Protein	Name	Similarity
Q9JLF1	—	1.000	Q9JLF1 →
P09483	—	0.988	P09483 →
A8XNX8	—	0.987	A8XNX8 →
P09482	—	0.987	P09482 →
P54246	—	0.987	P54246 →
CHRNA4	Neuronal acetylcholine receptor subunit alpha-4	0.985	landscape →
O70174	—	0.985	O70174 →
P41849	—	0.983	P41849 →
P48182	—	0.983	P48182 →
Q9GQ00	—	0.982	Q9GQ00 →
Q9ES14	—	0.982	Q9ES14 →
G5EDN0	—	0.981	G5EDN0 →
Q5IS77	—	0.981	Q5IS77 →
P54245	—	0.981	P54245 →
O18276	—	0.980	O18276 →
Q9ER47	—	0.979	Q9ER47 →
Q9TUI4	—	0.979	Q9TUI4 →
Q27218	—	0.979	Q27218 →
O54852	—	0.979	O54852 →
B4HS00	—	0.979	B4HS00 →
E1C2V1	—	0.978	E1C2V1 →
P17644	—	0.978	P17644 →
Q9QX29	—	0.978	Q9QX29 →
O35119	—	0.978	O35119 →
Q95Y52	—	0.977	Q95Y52 →
Q9NS40	—	0.977	Q9NS40 →
Q96L42	—	0.977	Q96L42 →
TRPC4	Short transient receptor potential channel 4	0.977	landscape →
G5ECT0	—	0.977	G5ECT0 →
F4JZ68	—	0.977	F4JZ68 →