Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21550306 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1ADORA2AADORA2BADORA1 | |
| SCHEMBL15498265 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1ADORA2AADORA2BADORA1 | |
| SCHEMBL16018360 | 0.83 | THRB (0.37) | KDM4EALDH1A1BACE1MAPTCYP1A2 | |
| SCHEMBL14830413 | 0.80 | CHRM1 (0.45) | KDM4EALDH1A1BACE1MAPTCYP1A2 | |
| SCHEMBL16018346 | 0.78 | THRB (0.37) | KDM4EALDH1A1MAPTCYP1A2LMNA | |
| SCHEMBL6528131 | 0.76 | KDM4E (0.44) | KDM4EALDH1A1ADORA2AADORA2BADORA1 | |
| SCHEMBL17484540 | 0.71 | HSD17B10 (0.49) | KDM4EBACE1MAPTCYP1A2LMNA | |
| SCHEMBL22516955 | 0.70 | MAPK1 (0.46) | KDM4EALDH1A1ADRA2AADRA2BADRA2C | |
| SCHEMBL8671763 | 0.69 | MAPT (0.41) | KDM4EALDH1A1ADORA2AADORA2BADORA1 | |
| SCHEMBL14578715 | 0.68 | BACE1 (0.81) | KDM4EALDH1A1BACE1MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170298021-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-10-19 | — | — | US | disclosed |
| US-20170298021-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-10-19 | — | — | US | disclosed |
| US-9732037-B2 | 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-08-15 | — | — | US | disclosed |
| US-9732037-B2 | 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-08-15 | — | — | US | disclosed |
| US-20160347713-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2016-12-01 | — | — | US | disclosed |
| US-20160347713-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2016-12-01 | — | — | US | disclosed |
| US-9416106-B2 | 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2016-08-16 | — | — | US | disclosed |
| US-9416106-B2 | 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2016-08-16 | — | — | US | disclosed |
| US-20150368201-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2015-12-24 | — | — | US | disclosed |
| US-20150368201-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2015-12-24 | — | — | US | disclosed |
| US-9120750-B2 | 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2015-09-01 | — | — | US | disclosed |
| US-9120750-B2 | 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2015-09-01 | — | — | US | disclosed |
| WO-2014138460-A1 | 2-AMINOPYRIDINE-BASED SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS | NORTHWESTERN UNIVERSITY (US) | 2014-09-12 | — | — | WO | disclosed |
| US-20140256016-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256016-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160347713-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NOS2, NOS1, NOS3 | KDM4E 1514/4885ALDH1A1 749/4885ADORA2A 859/4885 |
| US-20140256016-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NOS2, NOS1, NOS3 | KDM4E 1514/4885ALDH1A1 749/4885ADORA2A 859/4885 |
| US-20150368201-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NOS2, NOS1, NOS3 | KDM4E 1514/4885ALDH1A1 749/4885ADORA2A 859/4885 |
| US-20170298021-A1 | 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors | NOS2, NOS1, NOS3 | KDM4E 1514/4885ALDH1A1 749/4885ADORA2A 859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.