Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23159100 | 0.85 | PAOX (0.47) | MAPK1KDM4EHIF1AL3MBTL1PAOX | |
| SCHEMBL19821894 | 0.83 | MAPK1 (0.48) | MAPK1KDM4EHIF1AL3MBTL1PAOX | |
| SCHEMBL885125 | 0.80 | ALDH1A1 (0.62) | MAPK1KDM4EHIF1AL3MBTL1PAOX | |
| SCHEMBL11304559 | 0.79 | LPAR1 (0.56) | — | |
| SCHEMBL9783233 | 0.78 | ZDHHC7 (0.48) | MAPK1KDM4EHIF1APAOXALDH1A1 | |
| SCHEMBL21276665 | 0.77 | PAOX (0.46) | MAPK1KDM4EHIF1AL3MBTL1PAOX | |
| SCHEMBL28629985 | 0.74 | CYP2C19 (0.38) | MAPK1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL23175608 | 0.74 | KDM4E (0.58) | MAPK1KDM4EHIF1AL3MBTL1PAOX | |
| SCHEMBL13446672 | 0.74 | KDM4E (0.47) | MAPK1KDM4EHIF1AL3MBTL1PAOX | |
| SCHEMBL5668591 | 0.74 | KDM4E (0.56) | MAPK1KDM4EHIF1AL3MBTL1PAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9822353-B2 | PEGylated aspartyl-tRNA synthetase polypeptides | ATYR PHARMA, INC. (US) | 2017-11-21 | — | — | US | disclosed |
| US-9714419-B2 | PEGylated tyrosyl-tRNA synthetase polypeptides | ATYR PHARMA, INC. (US) | 2017-07-25 | — | — | US | disclosed |
| US-20150159148-A1 | PEGYLATED ASPARTYL-TRNA SYNTHETASE POLYPEPTIDES | ATYR PHARMA, INC. | 2015-06-11 | — | — | US | disclosed |
| US-20140255378-A1 | PEGYLATED TYROSYL-TRNA SYNTHETASE POLYPEPTIDES | ATYR PHARMA, INC (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150159148-A1 | PEGYLATED ASPARTYL-TRNA SYNTHETASE POLYPEPTIDES | AARS1, GARS1, DARS1 | MAPK1 4652/4885KDM4E 4368/4885HIF1A 3913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.