Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.39 |
| ▸ | ITGA1 | P56199 | 4/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.39 |
| ▸ | ITGAM | P11215 | 1/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.37 |
| ▸ | CTSG | P08311 | 2/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | PPM1D | O15297 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21973546 | 1.00 | KEAP1 (0.42) | KEAP1ITGB2ITGB1ITGA4ITGA1 | |
| SCHEMBL21973224 | 0.73 | TEAD4 (0.44) | KEAP1KDM1ARCOR1CTSGOPRM1 | |
| SCHEMBL16021588 | 0.73 | TEAD4 (0.44) | KEAP1KDM1ARCOR1CTSGOPRM1 | |
| SCHEMBL29875816 | 0.73 | TEAD4 (0.44) | KEAP1KDM1ARCOR1CTSGOPRM1 | |
| SCHEMBL20283327 | 0.72 | KLK7 (0.49) | KEAP1OPRM1OPRD1OPRK1 | |
| SCHEMBL16021609 | 0.66 | SOAT2 (0.43) | ITGB1ITGA4 | |
| SCHEMBL29885810 | 0.64 | GHSR (0.51) | — | |
| SCHEMBL24867898 | 0.64 | ITGB1 (0.38) | ITGB2ITGB1ITGA4ITGA1ITGB7 | |
| SCHEMBL22540885 | 0.64 | ITGB1 (0.38) | ITGB2ITGB1ITGA4ITGA1ITGB7 | |
| SCHEMBL3124456 | 0.64 | GAA (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160194360-A1 | PEPTIDE-BASED QUORUM SENSING INHIBITORS FOR THE ATTENUATION OF VIRULENCE IN STAPHYLOCOCCUS AUREUS | NAVY, SECRETARY OF THE UNITED STATES OF AMERICA | 2016-07-07 | — | — | US | disclosed |
| US-9227996-B2 | Peptide-based quorum sensing inhibitors for the attenuation of virulence in Staphylococcus aureus | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2016-01-05 | — | — | US | disclosed |
| US-20140256615-A1 | PEPTIDE-BASED QUORUM SENSING INHIBITORS FOR THE ATTENUATION OF VIRULENCE IN STAPHYLOCOCCUS AUREUS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160194360-A1 | PEPTIDE-BASED QUORUM SENSING INHIBITORS FOR THE ATTENUATION OF VIRULENCE IN STAPHYLOCOCCUS AUREUS | QRFPR, SCTR, SRRT | KEAP1 2115/4885ITGB2 4506/4885ITGB1 4154/4885 |
| US-20140256615-A1 | PEPTIDE-BASED QUORUM SENSING INHIBITORS FOR THE ATTENUATION OF VIRULENCE IN STAPHYLOCOCCUS AUREUS | QRFPR, SCTR, SRRT | KEAP1 2115/4885ITGB2 4506/4885ITGB1 4154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.