Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1603147 | 1.00 | KDM4E (0.31) | KDM4ELMNATP53POLBHTT | |
| SCHEMBL31756543 | 0.76 | — | — | |
| SCHEMBL1187321 | 0.76 | CA1 (0.34) | KMT2A | |
| SCHEMBL19822417 | 0.76 | — | — | |
| SCHEMBL822975 | 0.76 | — | — | |
| SCHEMBL231085 | 0.76 | — | — | |
| SCHEMBL9971744 | 0.76 | CA1 (0.34) | KMT2A | |
| SCHEMBL12524744 | 0.76 | POLB (0.31) | POLB | |
| SCHEMBL8361030 | 0.76 | PTPN1 (0.31) | ALDH1A1KMT2A | |
| SCHEMBL12555452 | 0.76 | ALDH1A1 (0.31) | LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2721004-B1 | 3-DESOXY-2-METHYLENE-19-NOR-VITAMIN D ANALOGS AND THEIR USES | WISCONSIN ALUMNI RES FOUND (US) | 2017-07-26 | — | — | EP | disclosed |
| US-8993547-B2 | 3-desoxy-2-methylene-19-nor-vitamin D analogs and their uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2015-03-31 | — | — | US | disclosed |
| EP-2483240-B1 | 1-DESOXY-2-METHYLENE-19-NOR-VITAMIN D ANALOGS AND THEIR USES | WISCONSIN ALUMNI RES FOUND (US) | 2014-09-03 | — | — | EP | disclosed |
| US-8642579-B2 | 1-desoxy-2-methylene-19-nor-vitamin D analogs and their uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-02-04 | — | — | US | disclosed |
| US-8518917-B2 | 2-methylene-19-nor-vitamin D analogs and their uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120322775-A1 | 3-Desoxy-2-Methylene-19-Nor-Vitamin D Analogs and Their Uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-12-20 | — | — | US | disclosed |
| US-20120157418-A1 | 2-Methylene-19-Nor-Vitamin D Analogs and Their Uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120040947-A1 | TETRALINE AND INDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | US | disclosed |
| US-20110082121-A1 | 1-Desoxy-2-Methylene-19-Nor-Vitamin D Analogs and Their Uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2011-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040947-A1 | TETRALINE AND INDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | SLC10A1, SUGT1, SLC10A2 | KDM4E 4609/4885LMNA 3508/4885TP53 2203/4885 |
| US-20110082121-A1 | 1-Desoxy-2-Methylene-19-Nor-Vitamin D Analogs and Their Uses | VDR, CYP24A1, CYP2R1 | KDM4E 2167/4885LMNA 2533/4885TP53 817/4885 |
| US-20120157418-A1 | 2-Methylene-19-Nor-Vitamin D Analogs and Their Uses | CYP24A1, CYP2R1, CYP27B1 | KDM4E 1199/4885LMNA 2277/4885TP53 716/4885 |
| US-20120322775-A1 | 3-Desoxy-2-Methylene-19-Nor-Vitamin D Analogs and Their Uses | VDR, CYP24A1, CYP2R1 | KDM4E 2303/4885LMNA 2029/4885TP53 583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.