Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CES2 | O00748 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28037222 | 0.81 | ITGB2 (0.44) | KMT2ACES2CES1LMNAALDH1A1 | |
| SCHEMBL8536465 | 0.76 | ERCC5 (0.42) | KMT2ATHRBADRB2ADRB1ADRB3 | |
| SCHEMBL8535121 | 0.76 | ADRB2 (0.45) | KMT2AADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL16042409 | 0.75 | HTT (0.48) | KMT2AAAK1ALDH1A1SMN1; SMN2CTSS | |
| SCHEMBL16042348 | 0.75 | RXFP1 (0.44) | KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8535820 | 0.73 | ALDH1A1 (0.46) | KMT2ALMNATHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL27497692 | 0.73 | AAK1 (0.36) | KMT2ALMNAAAK1ALDH1A1 | |
| SCHEMBL27498315 | 0.73 | SLC7A5 (0.47) | KMT2AAAK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16492258 | 0.72 | SCN9A (0.39) | KMT2AADRB2ADRB1ADRB3GPR119 | |
| SCHEMBL24834160 | 0.71 | ALDH1A1 (0.36) | KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970193-B1 | PYRROLE AMIDE INHIBITORS | ABBVIE INC (US) | 2018-07-25 | — | — | EP | disclosed |
| US-9493411-B2 | Pyrrole-3-carboxamide bromodomain inhibitors | ABBVIE INC. (US) | 2016-11-15 | — | — | US | disclosed |
| EP-2970193-A1 | PYRROLE AMIDE INHIBITORS | AbbVie Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014165127-A1 | PYRROLE AMIDE INHIBITORS | ABBVIE INC. (US) | 2014-10-09 | — | — | WO | disclosed |
| US-20140275079-A1 | PYRROLE AMIDE INHIBITORS | ABBVIE INC. | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275079-A1 | PYRROLE AMIDE INHIBITORS | HDAC10, ARG1, CDK20 | KMT2A 2286/4885CES2 2821/4885CES1 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.