Sugi Predict

Sugi Predict / Compounds / SCHEMBL1604355

SCHEMBL1604355

SCHEMBL1604355

CC(C)C1SC(Nc2c(Cl)cccc2Cl)=NC1=O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CXCL8 P10145 8/20 0.39
▸ ADRA2A P08913 3/20 0.35
▸ ADRA2C P18825 3/20 0.35
▸ ADRA2B P18089 2/20 0.35
▸ C1R P00736 2/20 0.33
▸ ADRA1A P35348 3/20 0.33
▸ ADRA1D P25100 2/20 0.33
▸ ADRA1B P35368 2/20 0.33
▸ RECQL P46063 1/20 0.32
▸ PTGS2 P35354 2/20 0.32
▸ AKR1B10 O60218 1/20 0.32
▸ UGT1A9 O60656 1/20 0.32
▸ TRPA1 O75762 1/20 0.32
▸ ABCB11 O95342 1/20 0.32
▸ MT-CO2 P00403 1/20 0.32
▸ TTR P02766 1/20 0.32
▸ ALB P02768 1/20 0.32
▸ UGT1A6 P19224 1/20 0.32
▸ UGT1A1 P22309 1/20 0.32
▸ PTGS1 P23219 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1605573 0.86 DHODH (0.38) ADRA2AADRA2CADRA2BC1RPTGS2
SCHEMBL1605128 0.85 NISCH (0.41) ADRA2AADRA1APTGS2MT-CO2TTR
SCHEMBL5549464 0.78 HPGD (0.46) RECQLPTGS2PTGS1LMNAALDH1A1
SCHEMBL1605706 0.76 GAA (0.45) LMNAALDH1A1HDAC3HDAC1HDAC2
SCHEMBL1383097 0.75 LMNA (0.51) C1RPTGS2PTGS1LMNAALDH1A1
SCHEMBL1605715 0.75 CXCL8 (0.30) CXCL8ALDH1A1HTT
SCHEMBL1383688 0.74 CCR4 (0.40) LMNAKMT2A
SCHEMBL1383748 0.74 HSD11B1 (0.39) C1RLMNAALDH1A1HTTMEN1
SCHEMBL1604638 0.74 TAAR1 (0.42) RECQLHDAC3HDAC1HDAC2HDAC6
SCHEMBL1605890 0.74 ROCK1 (0.38) ADRA2AADRA2CADRA2BADRA1ACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8541592-B2 Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 AMGEN INC. (US) 2013-09-24 — — US disclosed
US-8541592-B2 Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 AMGEN INC. (US) 2013-09-24 — — US disclosed
US-20120010256-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 BIOVITRUM AB 2012-01-12 — — US disclosed
US-20120010256-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 BIOVITRUM AB 2012-01-12 — — US disclosed
US-20110082107-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 AMGEN INC. 2011-04-07 — — US disclosed
US-20110082107-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 AMGEN INC. 2011-04-07 — — US disclosed
US-7807700-B2 Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 AMGEN INC. (US) 2010-10-05 — — US disclosed
US-7807700-B2 Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 AMGEN INC. (US) 2010-10-05 — — US disclosed
US-7807700-B2 Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 AMGEN INC. (US) 2010-10-05 — — US disclosed
EP-1753736-B1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 AMGEN INC (US) 2008-12-17 — — EP disclosed
US-20080045503-A1 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 AMGEN INC. 2008-02-21 — — US disclosed
US-20070281938-A1 Inhibitors of 11-Beta-Hydroxy Steroid Dehydrogenase Type 1 AMGEN INC. 2007-12-06 — — US disclosed
US-20070281938-A1 Inhibitors of 11-Beta-Hydroxy Steroid Dehydrogenase Type 1 AMGEN INC. 2007-12-06 — — US disclosed
US-20070197598-A1 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 AMGEN INC. 2007-08-23 — — US disclosed
US-20070197598-A1 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 AMGEN INC. 2007-08-23 — — US disclosed
US-7253196-B2 Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 AMGEN, INC. (US) 2007-08-07 — — US disclosed
US-7253196-B2 Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 AMGEN, INC. (US) 2007-08-07 — — US disclosed
EP-1753736-A2 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 Amgen Inc. (US) 2007-02-21 — — EP disclosed
US-20060142357-A1 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 AMGEN INC. 2006-06-29 — — US disclosed
WO-2005116002-A2 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 AMGEN INC. (US) 2005-12-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110082107-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 HSD11B1, HSD3B1, HSD17B1 CXCL8 4748/4885ADRA2A 447/4885ADRA2C 429/4885
US-20080045503-A1 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 HSD11B1, HSD3B1, HSD17B1 CXCL8 4748/4885ADRA2A 447/4885ADRA2C 429/4885
US-20070197598-A1 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 HSD11B1, HSD17B1, HSD11B2 CXCL8 4477/4885ADRA2A 868/4885ADRA2C 739/4885
US-20060142357-A1 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 HSD11B1, HSD3B1, HSD17B1 CXCL8 4748/4885ADRA2A 447/4885ADRA2C 429/4885
US-20120010256-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 HSD11B1, HSD3B1, HSD17B1 CXCL8 4748/4885ADRA2A 447/4885ADRA2C 429/4885
US-20070281938-A1 Inhibitors of 11-Beta-Hydroxy Steroid Dehydrogenase Type 1 HSD11B1, HSD3B1, HSD17B1 CXCL8 4685/4885ADRA2A 396/4885ADRA2C 437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.