Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 6/20 | 0.55 |
| ▸ | NAALAD2 | Q9Y3Q0 | 4/20 | 0.55 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.55 |
| ▸ | PKLR | P30613 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728438 | 0.81 | MME (0.45) | EPHX2GAA | |
| SCHEMBL2861077 | 0.81 | TGFBR1 (0.44) | EPHX2GAA | |
| Aceglumate SCHEMBL910300 | 0.79 | FOLH1 (0.46) | FOLH1NAALAD2RIMKLA | |
| Acetylglutamic Acid SCHEMBL910067 | 0.79 | FOLH1 (0.46) | FOLH1NAALAD2RIMKLA | |
| Acetylglutamic Acid SCHEMBL910770 | 0.79 | FOLH1 (0.46) | FOLH1NAALAD2RIMKLA | |
| Acetylglutamic Acid SCHEMBL910789 | 0.77 | FOLH1 (0.47) | FOLH1NAALAD2RIMKLA | |
| Aceglumate SCHEMBL910345 | 0.77 | FOLH1 (0.47) | FOLH1NAALAD2RIMKLA | |
| Acetylglutamic Acid SCHEMBL910760 | 0.77 | FOLH1 (0.47) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL1038171 | 0.77 | ECE1 (0.42) | GAA | |
| SCHEMBL7341199 | 0.77 | GAA (0.62) | FOLH1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11053252-B2 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-07-06 | — | — | US | claimed |
| US-20200190097-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2020-06-18 | — | — | US | claimed |
| US-10611767-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2020-04-07 | — | — | US | claimed |
| US-20180346474-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-12-06 | — | — | US | claimed |
| US-10000498-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-19 | — | — | US | claimed |
| EP-2995199-B1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | UNIV HOLY GHOST DUQUESNE (US) | 2018-03-14 | — | — | EP | claimed |
| US-20170114066-A1 | Selective Proton Coupled Folate Transporter and Folate Receptor, and Garftase Inhibitor Compounds and Methods of Using the Same | WAYNE STATE UNIVERSITY | 2017-04-27 | — | — | US | claimed |
| US-9511069-B2 | Selective proton coupled folate transporter and folate receptor, and GRAFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2016-12-06 | — | — | US | claimed |
| EP-2995199-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | Duquesne University of The Holy Spirit (US) | 2016-03-16 | — | — | EP | claimed |
| EP-2348843-B1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | UNIV HOLY GHOST DUQUESNE (US) | 2015-11-11 | — | — | EP | claimed |
| EP-2627332-A2 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | Duquesne University of The Holy Spirit (US) | 2013-08-21 | — | — | EP | claimed |
| US-20120295926-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2012-11-22 | — | — | US | claimed |
| WO-2012051105-A2 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2012-04-19 | — | — | WO | claimed |
| EP-2348843-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | Duquesne University of the Holy Ghost (US) | 2011-08-03 | — | — | EP | claimed |
| US-20110082158-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-04-07 | — | — | US | claimed |
| WO-2010039792-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2010-04-08 | — | — | WO | claimed |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | claimed |
| US-11053252-B2 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-07-06 | — | — | US | disclosed |
| WO-2010039792-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2010-04-08 | — | — | WO | disclosed |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000498-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | FOLH1 16/4885NAALAD2 2350/4885RIMKLA 1111/4885 |
| US-10611767-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | FOLH1 16/4885NAALAD2 2350/4885RIMKLA 1111/4885 |
| US-20200190097-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | FOLH1 16/4885NAALAD2 2350/4885RIMKLA 1111/4885 |
| US-20170114066-A1 | Selective Proton Coupled Folate Transporter and Folate Receptor, and Garftase Inhibitor Compounds and Methods of Using the Same | SLC46A1, SLC19A1, FOLR1 | FOLH1 16/4885NAALAD2 2350/4885RIMKLA 1111/4885 |
| US-20110082158-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, FOLR2, FOLR1 | FOLH1 6/4885NAALAD2 1529/4885RIMKLA 977/4885 |
| US-11053252-B2 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | FOLH1 16/4885NAALAD2 2350/4885RIMKLA 1111/4885 |
| US-20120295926-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | FOLH1 16/4885NAALAD2 2350/4885RIMKLA 1111/4885 |
| US-20180346474-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | FOLH1 16/4885NAALAD2 2350/4885RIMKLA 1111/4885 |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | FOLH1 16/4885NAALAD2 2350/4885RIMKLA 1111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.