Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.66 |
| ▸ | CA9 | Q16790 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29831664 | 1.00 | CA12 (0.66) | CA12CA9KMT2AMEN1LMNA | |
| SCHEMBL19886995 | 0.88 | KDM4E (0.72) | KMT2AMEN1LMNAKDM4EALDH1A1 | |
| SCHEMBL11571278 | 0.85 | KDM4E (0.59) | CA12CA9KMT2AMEN1LMNA | |
| SCHEMBL19891197 | 0.85 | KDM4E (0.68) | KMT2AMEN1LMNAKDM4EALDH1A1 | |
| SCHEMBL1414102 | 0.82 | SMN1; SMN2 (0.78) | CA12CA9KMT2AMEN1LMNA | |
| SCHEMBL12896373 | 0.81 | MAPT (0.63) | CA12CA9KMT2AMEN1LMNA | |
| SCHEMBL29923275 | 0.81 | MAPT (0.63) | CA12CA9KMT2AMEN1LMNA | |
| SCHEMBL9935900 | 0.81 | ALDH1A1 (0.75) | CA12CA9KMT2AMEN1LMNA | |
| SCHEMBL29389712 | 0.80 | KDM4E (0.71) | CA12CA9KMT2AMEN1LMNA | |
| SCHEMBL22388821 | 0.80 | KDM4E (0.71) | CA12CA9KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190084944-A1 | COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. (US) | 2019-03-21 | — | — | US | claimed |
| US-20160031837-A1 | COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. (US) | 2016-02-04 | — | — | US | claimed |
| EP-2970900-A1 | COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF | The Broad Institute, Inc. (US) | 2016-01-20 | — | — | EP | claimed |
| WO-2014144125-A1 | COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. (US) | 2014-09-18 | — | — | WO | claimed |
| EP-3998260-B1 | SGC STIMULATORS | CYCLERION THERAPEUTICS INC (US) | 2023-11-01 | — | — | EP | disclosed |
| CN-109369635-B | Compound or pharmaceutically acceptable salt thereof, application thereof and pharmaceutical composition | 赛克里翁治疗有限公司 | 2023-06-30 | — | — | CN | disclosed |
| US-11629132-B2 | Compounds for inducing proliferation and differentiation of cells, and methods of use thereof | THE BROAD INSTITUTE, INC. (US) | 2023-04-18 | — | — | US | disclosed |
| US-20230106002-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. | 2023-04-06 | — | — | US | disclosed |
| CN-109384778-B | Use of a compound or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of a disease, health condition or disorder | 赛克里翁治疗有限公司 | 2022-12-13 | — | — | CN | disclosed |
| CN-110016020-B | Compound or pharmaceutically acceptable salt thereof, application and pharmaceutical composition thereof | 赛克里翁治疗有限公司 | 2022-07-26 | — | — | CN | disclosed |
| EP-3998260-A1 | SGC STIMULATORS | Cyclerion Therapeutics, Inc. (US) | 2022-05-18 | — | — | EP | disclosed |
| EP-3660013-B1 | SGC STIMULATORS | CYCLERION THERAPEUTICS INC (US) | 2022-01-19 | — | — | EP | disclosed |
| US-20160031903-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-02-04 | — | — | US | disclosed |
| US-20160031837-A1 | COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. (US) | 2016-02-04 | — | — | US | disclosed |
| US-20160031837-A1 | COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. (US) | 2016-02-04 | — | — | US | disclosed |
| US-20160031837-A1 | COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. (US) | 2016-02-04 | — | — | US | disclosed |
| EP-2970900-A1 | COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF | The Broad Institute, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| EP-2970243-A2 | SGC STIMULATORS | Ironwood Pharmaceuticals, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014144125-A1 | COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014144100-A2 | SGC STIMULATORS | NAKAI TAKASHI (US) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230106002-A1 | sGC STIMULATORS | PTGIS, CGAS, GUCY1A1 | CA12 4513/4885CA9 3467/4885KMT2A 4250/4885 |
| US-11629132-B2 | Compounds for inducing proliferation and differentiation of cells, and methods of use thereof | MKI67, MCL1, CD14 | CA12 290/4885CA9 1708/4885KMT2A 2519/4885 |
| US-20190084944-A1 | COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF | MKI67, CD14, DCX | CA12 740/4885CA9 3421/4885KMT2A 2092/4885 |
| US-20160031837-A1 | COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF | HGF, HDGF, CD14 | CA12 401/4885CA9 2291/4885KMT2A 3345/4885 |
| US-20160031903-A1 | sGC STIMULATORS | PTGIS, CGAS, GUCY1A1 | CA12 4513/4885CA9 3467/4885KMT2A 4250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.