Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30149464 | 0.86 | LMNA (0.70) | POLBHIF1ALMNAMAPK1PDE4A | |
| SCHEMBL16028342 | 0.80 | TRPC4 (0.56) | POLBHIF1AMAPK1MAPTTRPC5 | |
| SCHEMBL16028126 | 0.78 | TRPC5 (0.54) | HIF1AMAPK1MAPTTRPC5SMN1; SMN2 | |
| SCHEMBL16028758 | 0.75 | TRPC5 (0.65) | POLBHIF1AMAPK1MAPTTRPC5 | |
| SCHEMBL7558655 | 0.75 | POLB (0.72) | POLBHIF1ALMNAMAPK1PDE4A | |
| SCHEMBL16028209 | 0.75 | PDE4A (0.58) | POLBLMNAPDE4ACYP1A2NFKB1 | |
| SCHEMBL17619844 | 0.75 | TRPA1 (0.74) | LMNAPDE4ACYP1A2NFKB1ACHE | |
| SCHEMBL9293614 | 0.75 | ADORA2B (0.71) | LMNAPDE4ACYP1A2NFKB1ACHE | |
| SCHEMBL9293292 | 0.75 | PDE4A (0.62) | LMNAPDE4ACYP1A2NFKB1ACHE | |
| SCHEMBL16364012 | 0.75 | TRPC5 (0.55) | HIF1AMAPK1CYP1A2MAPTTRPC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-A2 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | Hydra Biosciences, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014143799-A2 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES, INC. (US) | 2014-09-18 | — | — | WO | disclosed |