Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL243663 | 0.85 | CCR2 (0.49) | CCR2 | |
| SCHEMBL9001721 | 0.70 | CCR5 (0.46) | MGLLCCR5CES2CES1ALDH1A1 | |
| SCHEMBL9001722 | 0.70 | CES2 (0.44) | CCR5CES2CES1ALDH1A1HPGD | |
| SCHEMBL9001707 | 0.70 | CCR5 (0.49) | MGLLCCR5CES2CES1ALDH1A1 | |
| SCHEMBL3108291 | 0.69 | MGLL (0.40) | CCR2KDM4EMGLLPDE3BPDE3A | |
| SCHEMBL9001720 | 0.67 | CCR5 (0.43) | MGLLCCR5CES2CES1ALDH1A1 | |
| SCHEMBL9001740 | 0.67 | CCR5 (0.47) | MGLLCCR5CES2CES1ALDH1A1 | |
| SCHEMBL16938641 | 0.67 | CES2 (0.50) | CES2CES1ALDH1A1TSHRLMNA | |
| SCHEMBL761357 | 0.67 | CES2 (0.50) | CES2CES1ALDH1A1TSHRLMNA | |
| SCHEMBL9001724 | 0.66 | FAAH (0.47) | MGLLCCR5CES2CES1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014144547-A2 | AMIDE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-09-18 | — | — | WO | disclosed |