Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899999 | 0.83 | ALDH1A1 (0.39) | ALDH1A1ALOX15CYP2D6CYP1A2MAPK1 | |
| SCHEMBL4367368 | 0.81 | MAPK1 (0.42) | ALDH1A1ALOX15CYP2D6CYP1A2MAPK1 | |
| SCHEMBL663135 | 0.80 | ALDH1A1 (0.45) | ALDH1A1ALOX15CYP2D6CYP1A2MAPK1 | |
| SCHEMBL27413509 | 0.77 | MAPK1 (0.39) | ALDH1A1ALOX15CYP2D6CYP1A2MAPK1 | |
| SCHEMBL8813285 | 0.77 | MAPK1 (0.39) | ALDH1A1ALOX15CYP2D6CYP1A2MAPK1 | |
| SCHEMBL3812105 | 0.77 | CYP1A2 (0.46) | ALDH1A1ALOX15CYP2D6CYP1A2KCNN4 | |
| SCHEMBL8868519 | 0.77 | CYP1A2 (0.46) | ALDH1A1ALOX15CYP2D6CYP1A2KCNN4 | |
| SCHEMBL16551069 | 0.77 | LMNA (0.42) | ALDH1A1ALOX15CYP2D6MAPK1KCNN4 | |
| SCHEMBL3529955 | 0.77 | TRPA1 (0.38) | ALDH1A1ALOX15CYP2D6CYP1A2MAPK1 | |
| SCHEMBL3529956 | 0.77 | TRPA1 (0.38) | ALDH1A1ALOX15CYP2D6CYP1A2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970147-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-1-((1S,4R, 5S)-2-FLUORO-4,5-DIHYDROXY-3-HYDROXYMETHYL-CYCLOPENT-2-ENYL)-1H-PYRIMIDIN-2-ONE | Rexahn Pharmaceuticals, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| EP-2845587-A2 | Melanin production inhibitor | Pola Chemical Industries Inc. (JP) | 2015-03-11 | — | — | EP | disclosed |
| WO-2014145807-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-1-((1S,4R, 5S)-2-FLUORO-4,5-DIHYDROXY-3-HYDROXYMETHYL-CYCLOPENT-2-ENYL)-1H-PYRIMIDIN-2-ONE | REXAHN PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |