Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 8/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69432 | 0.80 | NOTUM (0.60) | NOTUMTSHRMAPTL3MBTL1TP53 | |
| SCHEMBL27228706 | 0.78 | NOTUM (0.55) | NOTUMTSHRMAPTHPGDL3MBTL1 | |
| SCHEMBL17694561 | 0.76 | NOTUM (0.78) | NOTUMTSHRMAPTHPGDTP53 | |
| SCHEMBL22312193 | 0.74 | TSHR (0.55) | NOTUMTSHRMAPTESR1POLB | |
| SCHEMBL2610163 | 0.74 | NOTUM (0.75) | NOTUMTSHRMAPTHPGDTP53 | |
| SCHEMBL10020269 | 0.72 | GSK3B (0.76) | TSHRMAPTPOLBHPGDL3MBTL1 | |
| SCHEMBL3685411 | 0.71 | NOTUM (0.64) | NOTUMTSHRMAPTHPGDTP53 | |
| SCHEMBL860256 | 0.71 | NOTUM (0.64) | NOTUMTSHRMAPTHPGDL3MBTL1 | |
| SCHEMBL19976499 | 0.69 | MLYCD (0.46) | NOTUMTSHR | |
| SCHEMBL29236054 | 0.69 | NOTUM (0.56) | NOTUMTSHRMAPTESR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014139008-A1 | SMALL MOLECULE MODULATORS OF PCSK9 AND METHODS OF USE THEREOF | ADAERATA, LIMITED PARTNERSHIP (CA) | 2014-09-18 | — | — | WO | disclosed |