Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16095837 | 0.82 | KDM4C (0.36) | KDM4CGRM5JAK2TYK2KCNH2 | |
| SCHEMBL16095272 | 0.75 | NPY5R (0.35) | KCNH2NPY5R | |
| SCHEMBL16094450 | 0.74 | NPY5R (0.34) | LRRK2KCNH2NPY5R | |
| SCHEMBL16095178 | 0.74 | KDM4C (0.36) | KDM4CGRM5KCNH2 | |
| SCHEMBL16033875 | 0.71 | NPY5R (0.38) | KDM4CGRM5METAP2METAP1KCNH2 | |
| SCHEMBL16095192 | 0.70 | MGLL (0.38) | TYK2KCNH2NPY5R | |
| SCHEMBL17604548 | 0.68 | NPY5R (0.38) | KDM4CGRM5METAP2METAP1KCNH2 | |
| SCHEMBL16095225 | 0.67 | NPY5R (0.41) | KCNH2NPY5R | |
| SCHEMBL16034110 | 0.66 | KDM4C (0.59) | KDM4CGRM5 | |
| SCHEMBL16032441 | 0.66 | KMO (0.42) | KDM4CKCNH2NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2969007-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals Inc (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151945-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |