Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | GLRA1 | P23415 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25430153 | 0.80 | KDM1A (0.48) | FEN1KDM1ARXRARXRBRXRG | |
| SCHEMBL8565737 | 0.76 | KDM1A (0.55) | FEN1KDM1ALMNAMAOBMAOA | |
| SCHEMBL27982373 | 0.76 | BRD4 (0.49) | KDM1ABRD4NPC1PTGER1MAOB | |
| SCHEMBL3617567 | 0.74 | PTPN1 (0.61) | KDM1ALMNAHPGDBRD4NPC1 | |
| SCHEMBL14882717 | 0.74 | KDM1A (0.60) | KDM1ALMNAMAOBMAOA | |
| SCHEMBL29216487 | 0.73 | KDM1A (0.50) | KDM1ALMNAHPGDMAOBPTPN1 | |
| SCHEMBL26942220 | 0.73 | LIPE (0.53) | KDM1ALMNAHPGDBRD4NPC1 | |
| SCHEMBL25946412 | 0.71 | FEN1 (0.52) | FEN1KDM1ALMNAHPGDRXRA | |
| SCHEMBL25365036 | 0.71 | CTSV (0.52) | LMNAHPGDNPC1PTGER1SRD5A2 | |
| SCHEMBL16096561 | 0.71 | PTPN1 (0.45) | KDM1ALMNAHPGDNPC1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3114111-A1 | BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 | Janssen Pharmaceutica NV (BE) | 2017-01-11 | — | — | EP | disclosed |
| EP-2970182-A1 | BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 | Janssen Pharmaceutica, N.V. (BE) | 2016-01-20 | — | — | EP | disclosed |
| WO-2015134038-A1 | BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 | JANSSEN PHARMACEUTICA NV (BE) | 2015-09-11 | — | — | WO | disclosed |
| WO-2014149987-A1 | BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-25 | — | — | WO | disclosed |