SCHEMBL16099412

SCHEMBL16099412

CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ADORA2B P29275 20/20 1.00
ADORA2A P29274 18/20 1.00
ADORA1 P30542 12/20 1.00
ADORA3 P0DMS8 4/20 0.87

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17387706 0.90 ADORA2B (1.00) ADORA2BADORA2AADORA1ADORA3
SCHEMBL1223271 0.79 ADORA2B (1.00) ADORA2BADORA2AADORA1ADORA3
SCHEMBL20883015 0.77 ADORA2B (0.77) ADORA2BADORA2AADORA1ADORA3
SCHEMBL4054089 0.77 ADORA2B (0.73) ADORA2BADORA2AADORA1ADORA3
SCHEMBL4055179 0.76 ADORA2B (0.82) ADORA2BADORA2AADORA1ADORA3
SCHEMBL25090489 0.76 ADORA2B (0.73) ADORA2BADORA2AADORA1ADORA3
SCHEMBL19520833 0.75 ADORA2B (0.59) ADORA2BADORA2AADORA1ADORA3
SCHEMBL4051557 0.75 ADORA2B (0.77) ADORA2BADORA2AADORA1ADORA3
SCHEMBL29494961 0.72 ADORA2B (1.00) ADORA2BADORA2AADORA1ADORA3
SCHEMBL4058551 0.71 ADORA2B (0.76) ADORA2BADORA2AADORA1ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240219394-A1 METHOD FOR MEASURING RESPONSE OF OLFACTORY RECEPTOR TO SUBSTANCE AJINOMOTO CO., INC. (JP) 2024-07-04 US claimed
EP-4382612-A1 METHOD FOR MEASURING RESPONSE OF OLFACTORY RECEPTOR TO SUBSTANCE AJINOMOTO CO., INC. (JP) 2024-06-12 EP claimed
WO-2023013791-A1 METHOD FOR MEASURING RESPONSE OF OLFACTORY RECEPTOR TO SUBSTANCE 味の素株式会社 2023-02-09 WO claimed
US-12569445-B2 Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof HALOZYME HYPERCON, INC. (US) 2026-03-10 US disclosed
US-12558323-B2 Particle formation and morphology ELEKTROFI, INC. (US) 2026-02-24 US disclosed
US-20260007615-A1 PARTICLES COMPRISING A THERAPEUTIC OR DIAGNOSTIC AGENT AND SUSPENSIONS AND METHODS OF USE THEREOF ELEKTROFI INC (US) 2026-01-08 US disclosed
US-20260000616-A1 METHODS OF FORMING PARTICLES BY CONTINUOUS DROPLET FORMATION AND DEHYDRATION ELEKTROFI INC (US) 2026-01-01 US disclosed
EP-3908601-B1 COMPOSITIONS FOR TREATING CANCER OMEROS CORP (US) 2025-12-24 EP disclosed
US-20250383333-A1 DETERMINATION OF PARTICULATE CONTAMINANTS IN PARTICLES AND COMPOSITIONS ELEKTROFI INC (US) 2025-12-18 US disclosed
US-12433849-B2 Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof ELEKTROFI, INC. (US) 2025-10-07 US disclosed
US-20250288525-A1 METHODS OF FORMING PARTICLES BY CONTINUOUS DROPLET FORMATION AND DEHYDRATION HALOZYME HYPERCON, INC. 2025-09-18 US disclosed
US-20220249663-A1 METHODS AND COMPOSITIONS FOR CANCER TREATMENT AND TREATMENT SELECTION APELLIS PHARMACEUTICALS, INC. 2022-08-11 US disclosed
EP-4027989-A1 METHODS OF TREATING CANCER Inspirna, Inc. (US) 2022-07-20 EP disclosed
US-11376255-B2 Thiocarbamate derivatives as A2A inhibitors, pharmaceutical composition thereof and combinations with anticancer agents iTeos Belgium SA (BE) 2022-07-05 US disclosed
US-11274158-B2 Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators FLAGSHIP PIONEERING INNOVATIONS V, INC. (US) 2022-03-15 US disclosed
WO-2022050230-A1 COMPOSITION INHIBITING ACTIVATION OF ADENOSINE RECEPTOR 学校法人埼玉医科大学 2022-03-10 WO disclosed
WO-2022040246-A1 IMMUNE MODULATION OF MYELOID DERIVED SUPPRESSIVE CELL FUNCTION FOR CANCER TREATMENT STIMIT CORPORATION (US) 2022-02-24 WO disclosed
US-20220054499-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2022-02-24 US disclosed
US-20200345725-A1 Methods and Compositions for Treating Cancer OMEROS CORPORATOIN 2020-11-05 US disclosed
WO-2014153424-A1 REDUCING DIABETES IN PATIENTS RECEIVING HMG-COA REDUCTASE INHIBITORS (STATINS) LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY (US) 2014-09-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260000616-A1 METHODS OF FORMING PARTICLES BY CONTINUOUS DROPLET FORMATION AND DEHYDRATION ALB, TNF, TTR ADORA2B 4301/4885ADORA2A 3439/4885ADORA1 4507/4885
US-11376255-B2 Thiocarbamate derivatives as A2A inhibitors, pharmaceutical composition thereof and combinations with anticancer agents ADORA2A, ADORA2B, ADORA1 ADORA2B 2/4885ADORA2A 1/4885ADORA1 3/4885
US-12569445-B2 Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof ALB, S100P, S100A8 ADORA2B 3145/4885ADORA2A 2833/4885ADORA1 2871/4885
US-20220054499-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION MKI67, MYLK2, MYH2 ADORA2B 4319/4885ADORA2A 3845/4885ADORA1 4137/4885
US-12558323-B2 Particle formation and morphology CD63, EXOSC10, EPCAM ADORA2B 4009/4885ADORA2A 3001/4885ADORA1 3176/4885
US-20260007615-A1 PARTICLES COMPRISING A THERAPEUTIC OR DIAGNOSTIC AGENT AND SUSPENSIONS AND METHODS OF USE THEREOF FLNB, FLNA, FUS ADORA2B 1022/4885ADORA2A 3104/4885ADORA1 2292/4885
US-20200345725-A1 Methods and Compositions for Treating Cancer LPAR5, LPAR3, LPAR1 ADORA2B 637/4885ADORA2A 133/4885ADORA1 792/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.