Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 4/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16128163 | 0.82 | ALOX15 (0.46) | ALOX15CCR1ACHEHTR4KDM4E | |
| SCHEMBL16101072 | 0.80 | OPRM1 (0.46) | ALOX15CHEK1NTRK1METPIM1 | |
| SCHEMBL16128161 | 0.80 | OPRM1 (0.45) | ALOX15ALDH1A1CCR1ACHEHTR4 | |
| SCHEMBL3590004 | 0.80 | DRD2 (0.56) | ALDH1A1ACHEMEN1KMT2AROCK2 | |
| SCHEMBL5857232 | 0.79 | CCR5 (0.51) | — | |
| SCHEMBL16128082 | 0.77 | KDM4E (0.65) | CCR1ROCK2KDM4EGAAMAPT | |
| SCHEMBL16128166 | 0.77 | KDM4E (0.65) | CCR1ROCK2KDM4EGAAMAPT | |
| SCHEMBL16128279 | 0.77 | KDM4E (0.65) | CCR1ROCK2KDM4EGAAMAPT | |
| SCHEMBL5857349 | 0.75 | CCR5 (0.43) | ALDH3A1 | |
| SCHEMBL16101500 | 0.73 | OPRM1 (0.46) | CCR1ACHEHTR4KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9656994-B2 | Substituted benzimidazoles as nociceptin receptor modulators | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-05-23 | — | — | US | disclosed |
| EP-2976077-A1 | SUBSTITUTED BENZIMIDAZOLES AS NOCICEPTIN RECEPTOR MODULATORS | The Scripps Research Institute (US) | 2016-01-27 | — | — | EP | disclosed |
| WO-2014153529-A1 | SUBSTITUTED BENZIMIDAZOLES AS NOCICEPTIN RECEPTOR MODULATORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014153529-A1 | SUBSTITUTED BENZIMIDAZOLES AS NOCICEPTIN RECEPTOR MODULATORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-09-25 | — | — | WO | disclosed |