Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22030723 | 0.88 | CNR1 (0.43) | TSHRCDC7DBF4ALDH1A1HPGD | |
| SCHEMBL1712444 | 0.85 | TSHR (0.56) | TSHRALDH1A1HPGDKDM4EERN1 | |
| SCHEMBL1712613 | 0.83 | TSHR (0.53) | TSHRCDC7DBF4ALDH1A1HPGD | |
| SCHEMBL16107035 | 0.82 | SMN1; SMN2 (0.53) | HPGDKDM4ELMNATP53SMN1; SMN2 | |
| SCHEMBL7611832 | 0.82 | PPARG (0.52) | TSHRPPARGALDH1A1HPGDKDM4E | |
| SCHEMBL3683272 | 0.80 | TSHR (0.80) | TSHRALDH1A1KDM4EERN1LMNA | |
| SCHEMBL29617021 | 0.80 | TSHR (0.80) | TSHRALDH1A1KDM4EERN1LMNA | |
| SCHEMBL5154594 | 0.79 | ALDH1A1 (0.61) | TSHRALDH1A1HPGDKDM4EERN1 | |
| SCHEMBL13776773 | 0.79 | SLC6A2 (0.60) | TSHRPPARGALDH1A1HPGDKDM4E | |
| SCHEMBL7710797 | 0.78 | ALDH1A1 (0.57) | TSHRPPARGALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3805205-A1 | PYRAZOLE-AMIDE COMPOUND AND MEDICINAL USES THEREFOR | Japan Tobacco Inc. (JP) | 2021-04-14 | — | — | EP | disclosed |
| US-20200163937-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2020-05-28 | — | — | US | disclosed |
| US-20200163937-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2020-05-28 | — | — | US | disclosed |
| US-20180256547-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2018-09-13 | — | — | US | disclosed |
| EP-3348545-A1 | PYRAZOLE-AMIDE COMPOUND AND MEDICINAL USES THEREFOR | Japan Tobacco Inc. (JP) | 2018-07-18 | — | — | EP | disclosed |
| EP-2975028-B1 | PYRAZOLE-AMIDE COMPOUND AND MEDICINAL USES THEREFOR | JAPAN TOBACCO INC (JP) | 2018-02-21 | — | — | EP | disclosed |
| US-20160074364-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2016-03-17 | — | — | US | disclosed |
| US-20160074364-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2016-03-17 | — | — | US | disclosed |
| US-20160074364-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2016-03-17 | — | — | US | disclosed |
| EP-2975028-A1 | PYRAZOLE-AMIDE COMPOUND AND MEDICINAL USES THEREFOR | Japan Tobacco, Inc. (JP) | 2016-01-20 | — | — | EP | disclosed |
| US-9040717-B2 | Pyrazole-amide compounds and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2015-05-26 | — | — | US | disclosed |
| US-9040717-B2 | Pyrazole-amide compounds and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2015-05-26 | — | — | US | disclosed |
| US-9040717-B2 | Pyrazole-amide compounds and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2015-05-26 | — | — | US | disclosed |
| US-20150025120-A1 | PYRAZOLE-ALCOHOL COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2015-01-22 | — | — | US | disclosed |
| US-20150025120-A1 | PYRAZOLE-ALCOHOL COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2015-01-22 | — | — | US | disclosed |
| US-20150025120-A1 | PYRAZOLE-ALCOHOL COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2015-01-22 | — | — | US | disclosed |
| US-20140296315-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2014-10-02 | — | — | US | disclosed |
| US-20140296315-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2014-10-02 | — | — | US | disclosed |
| US-20140296315-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2014-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296315-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | NAT1, CYP2C19, CYP3A5 | TSHR 1979/4885CDC7 4421/4885DBF4 4091/4885 |
| US-20150025120-A1 | PYRAZOLE-ALCOHOL COMPOUNDS AND PHARMACEUTICAL USE THEREOF | ADH5, ADH1A, CYP3A43 | TSHR 2319/4885CDC7 4253/4885DBF4 4369/4885 |
| US-20180256547-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | NAT1, CYP2C19, CYP3A5 | TSHR 1979/4885CDC7 4421/4885DBF4 4091/4885 |
| US-20160074364-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | NAT1, CYP2C19, CYP3A5 | TSHR 1979/4885CDC7 4421/4885DBF4 4091/4885 |
| US-20200163937-A1 | PYRAZOLE-AMIDE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | NAT1, CYP2C19, CYP3A5 | TSHR 1979/4885CDC7 4421/4885DBF4 4091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.