Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9951781 | 0.83 | MEN1 (0.55) | PIM1PIM2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5690412 | 0.81 | PIM1 (0.46) | PIM1PIM2ALOX5LMNASMN1; SMN2 | |
| SCHEMBL2524154 | 0.77 | L3MBTL1 (0.52) | ALOX5LMNASMN1; SMN2RAB9AMAOB | |
| SCHEMBL22980373 | 0.76 | GABRG2 (0.42) | SMN1; SMN2MEN1KMT2AMAOBGABRG2 | |
| SCHEMBL8509535 | 0.76 | L3MBTL1 (0.46) | ALOX5LMNAMAOBGABRG2GABRB3 | |
| SCHEMBL29680880 | 0.76 | L3MBTL1 (0.46) | ALOX5LMNAMAOBGABRG2GABRB3 | |
| SCHEMBL15228636 | 0.76 | BACE1 (0.49) | PIM1PIM2BACE1LMNASMN1; SMN2 | |
| SCHEMBL16135206 | 0.75 | MCHR1 (0.52) | BACE1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL1010648 | 0.75 | MEN1 (0.53) | ALOX5SMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL29574709 | 0.75 | HTR7 (0.51) | ALOX5MAOBGABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027600-A1 | 1,4-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND THEIR USE FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS | Novartis AG (CH) | 2016-06-08 | — | — | EP | disclosed |
| WO-2015017589-A1 | 1,4-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND THEIR USE FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS | NOVARTIS AG (CH) | 2015-02-05 | — | — | WO | disclosed |
| US-20140296528-A1 | 4-ARYL-1-(BIARYLMETHYLENE) PIPERIDINE COMPOUNDS | KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY (SA) | 2014-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296528-A1 | 4-ARYL-1-(BIARYLMETHYLENE) PIPERIDINE COMPOUNDS | HTR2C, HTR3C, HTR1D | PIM1 2355/4885PIM2 1533/4885BACE1 2190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.