Sugi Predict

Sugi Predict / Compounds / SCHEMBL1010648

SCHEMBL1010648

SCHEMBL1010648

c1ccc(COc2ccc3ccccc3n2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.53
▸ MAPT P10636 1/20 0.53
▸ KMT2A Q03164 1/20 0.53
▸ CYP3A4 P08684 1/20 0.53
▸ STAT3 P40763 1/20 0.53
▸ HTT P42858 1/20 0.53
▸ SMN1; SMN2 Q16637 1/20 0.53
▸ CYSLTR2 Q9NS75 2/20 0.50
▸ CYSLTR1 Q9Y271 2/20 0.50
▸ ALOX5 P09917 1/20 0.50
▸ ADAMTS4 O75173 1/20 0.49
▸ PDE10A Q9Y233 1/20 0.49
▸ L3MBTL1 Q9Y468 1/20 0.49
▸ PKM P14618 1/20 0.45
▸ PDE5A O76074 1/20 0.45
▸ GRM5 P41594 1/20 0.44
▸ HDAC1 Q13547 1/20 0.44
▸ HDAC8 Q9BY41 1/20 0.44
▸ HDAC6 Q9UBN7 1/20 0.44
▸ ELANE P08246 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28230139 0.98 CYP3A4 (0.55) MEN1MAPTKMT2ACYP3A4STAT3
SCHEMBL9485359 0.90 ADAMTS4 (0.57) MEN1MAPTKMT2ACYP3A4STAT3
SCHEMBL6627563 0.88 MEN1 (0.49) MEN1MAPTKMT2ACYP3A4STAT3
SCHEMBL8621924 0.86 LMNA (0.50) MEN1MAPTKMT2ACYP3A4STAT3
SCHEMBL28787263 0.86 CYSLTR1 (0.52) MEN1MAPTKMT2ACYP3A4STAT3
SCHEMBL6089769 0.84 CYSLTR1 (0.53) MEN1MAPTKMT2ACYP3A4STAT3
SCHEMBL10858970 0.84 CYP3A4 (0.56) MAPTCYP3A4STAT3HTTSMN1; SMN2
SCHEMBL27324326 0.84 MEN1 (0.59) MEN1MAPTKMT2ACYP3A4STAT3
SCHEMBL14763914 0.83 CYP3A4 (0.48) MEN1KMT2ACYP3A4STAT3HTT
SCHEMBL19745071 0.82 MAOB (0.51) MEN1MAPTKMT2ACYP3A4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112931513-A Bactericide, preparation method and application thereof 菏泽龙歌植保技术有限公司 2021-06-11 — — CN claimed
US-10125226-B2 Scale-up process of bifunctionalized triblock copolymers with secondary and tertiary amines, with application in dewatering and desalting of heavy crude oils INSTITUTO MEXICANO DEL PETROLEO (MX) 2018-11-13 — — US claimed
US-20140364566-A1 SCALE-UP PROCESS OF BIFUNCTIONALIZED TRIBLOCK COPOLYMERS WITH SECONDARY AND TERTIARY AMINES, WITH APPLICATION IN DEWATERING AND DESALTING OF HEAVY CRUDE OILS INSTITUTO MEXICANO DEL PETROLEO (MX) 2014-12-11 — — US claimed
CN-1747732-A 2-aminocarbonyl-quinoline compounds as platelet adenosine diphosphate receptor antagonists SCHERING AG (DE) 2006-03-15 — — CN claimed
CN-112931513-A Bactericide, preparation method and application thereof 菏泽龙歌植保技术有限公司 2021-06-11 — — CN disclosed
CN-112931513-A Bactericide, preparation method and application thereof 菏泽龙歌植保技术有限公司 2021-06-11 — — CN disclosed
US-10167388-B2 Block copolymers, synthesis and application as dehydrating and desalting of heavy crudes INSTITUTO MEXICANO DEL PETROLEO (MX) 2019-01-01 — — US disclosed
CN-107382983-A A kind of synthetic method for treating leukemia medicament 扬州市三药制药有限公司 2017-11-24 — — CN disclosed
US-20170327686-A1 BLOCK COPOLYMERS, SYNTHESIS AND APPLICATION AS DEHYDRATING AND DESALTING OF HEAVY CRUDES MEXICANO INST PETROL (MX) 2017-11-16 — — US disclosed
US-9752084-B2 Block copolymers, synthesis and application as dehydrating and desalting of heavy crudes INSTITUTO MEXICANO DEL PETROLEO (MX) 2017-09-05 — — US disclosed
EP-2393801-B1 INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 JANSSEN PHARMACEUTICA NV (BE) 2017-07-12 — — EP disclosed
CN-102307868-B Indole derivatives as anticarcinogen 詹森药业有限公司 2016-06-22 — — CN disclosed
CN-1747732-A 2-aminocarbonyl-quinoline compounds as platelet adenosine diphosphate receptor antagonists SCHERING AG (DE) 2006-03-15 — — CN disclosed
US-6627406-B1 Maintaining volume in liquid zone, having a exposed opening to the atmosphere, by replenishing with medium from a reservoir connected to a capillary channel ACLARA BIOSCIENCES, INC. 2003-09-30 — — US disclosed
US-20030068646-A1 Sample evaporative control SINGH SHARAT (US) 2003-04-10 — — US disclosed
US-20020182749-A1 Sample evaporative control ACLARA BIOSCIENCES, INC. 2002-12-05 — — US disclosed
CN-1354691-A Method and device for sample evaporative control ACLARA BIOSCIENCES INC (US) 2002-06-19 — — CN disclosed
EP-1119412-A2 SAMPLE EVAPORATIVE CONTROL Aclara BioSciences, Inc. (US) 2001-08-01 — — EP disclosed
WO-2000067907-A2 SAMPLE EVAPORATIVE CONTROL ACLARA BIOSCIENCES, INC. (US) 2000-11-16 — — WO disclosed
CN-1102527-A Piperazinocarbonylcarbostyrils as peripheral vasodilators OTSUKA PHARMA CO LTD (JP) 1995-05-10 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10167388-B2 Block copolymers, synthesis and application as dehydrating and desalting of heavy crudes DEGS1, AQP1, AQP3 MEN1 4493/4885MAPT 3902/4885KMT2A 3805/4885
US-20170327686-A1 BLOCK COPOLYMERS, SYNTHESIS AND APPLICATION AS DEHYDRATING AND DESALTING OF HEAVY CRUDES DEGS1, AQP1, AQP3 MEN1 4493/4885MAPT 3902/4885KMT2A 3805/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.