Chloramphenicol

Chloramphenicol

SCHEMBL16111

O=C(N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)C(Cl)Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Chloramphenicol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 1.00
CYP3A4 P08684 3/20 1.00
TSHR P16473 2/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
ALDH1A1 P00352 1/20 1.00
MARS2 Q96GW9 1/20 1.00
CYP2C19 P33261 1/20 1.00
RPLP1 P05386 1/20 0.90
RPLP0 P05388 1/20 0.90
RPS17 P08708 1/20 0.90
RPSA P08865 1/20 0.90
RPS2 P15880 1/20 0.90
RPL35A P18077 1/20 0.90
RPL7 P18124 1/20 0.90
RPL17 P18621 1/20 0.90
RPS4Y1 P22090 1/20 0.90
RPS3 P23396 1/20 0.90
RPS12 P25398 1/20 0.90
RPL13 P26373 1/20 0.90
RPL10 P27635 1/20 0.90

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chloramphenicol SCHEMBL4262903 1.00 LMNA (1.00) LMNACYP3A4TSHRSMN1; SMN2ALDH1A1
Chloramphenicol SCHEMBL28181476 1.00 LMNA (1.00) LMNACYP3A4TSHRSMN1; SMN2ALDH1A1
Chloramphenicol SCHEMBL49057 1.00 LMNA (1.00) LMNACYP3A4TSHRSMN1; SMN2ALDH1A1
Chloramphenicol SCHEMBL29557257 1.00 LMNA (1.00) LMNACYP3A4TSHRSMN1; SMN2ALDH1A1
Chloramphenicol SCHEMBL4295048 1.00 LMNA (1.00) LMNACYP3A4TSHRSMN1; SMN2ALDH1A1
Chloramphenicol SCHEMBL537158 1.00 LMNA (1.00) LMNACYP3A4TSHRSMN1; SMN2ALDH1A1
Chloramphenicol SCHEMBL11131056 0.99 LMNA (0.97) LMNACYP3A4TSHRSMN1; SMN2ALDH1A1
Chloramphenicol SCHEMBL41042 0.99 LMNA (0.97) LMNACYP3A4TSHRSMN1; SMN2ALDH1A1
Chloramphenicol SCHEMBL20531030 0.99 LMNA (0.97) LMNACYP3A4TSHRSMN1; SMN2ALDH1A1
Chloramphenicol SCHEMBL28607485 0.99 LMNA (0.97) LMNACYP3A4TSHRSMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 208986 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144896-A1 MODIFIED CPG DINUCLEOTIDES FOR RECOMBINANT VIRAL VECTOR PRODUCTION SIREN BIOTECHNOLOGY, INC. (US) 2026-05-28 US claimed
CN-122081121-A Preparation method and application of athlete-source bifidobacterium probiotics for intestinal barrier repair 2026-05-26 CN claimed
CN-122081367-A Traceless gene editing system of Sphingomonas and application 2026-05-26 CN claimed
CN-115976082-B Resistance marker gene-free recombinant plasmid for expressing cumin, construction method and application thereof SOUTH CHINA UNIVERSITY OF TECHNOLOGY (CN) 2026-05-26 CN claimed
CN-122081189-A Dual-function engineering magnetotactic bacteria, construction method, imaging method realized by same and application 2026-05-26 CN claimed
CN-122081441-A Isolated kudria Pichia pastoris method 2026-05-26 CN claimed
CN-122071676-A Lactobacillus delbrueckii subspecies bulgaricus with ester aroma and taste of fermented yoghourt and application thereof 内蒙古伊利实业集团股份有限公司 2026-05-22 CN claimed
US-20260137809-A1 GENE THERAPY VECTORS FOR TREATMENT OF CANCER SIREN BIOTECHNOLOGY INC (US) 2026-05-21 US claimed
WO-2026106917-A1 EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL BioPhysics Pharma, Inc. (US) 2026-05-21 WO claimed
WO-2026104587-A1 CYCLIC BORONIC ACID ESTERS USEFUL AS ADJUVANTS IN THE TREATMENT OF BACTERIAL INFECTIONS ADJUTEC PHARMA AS (NO) 2026-05-21 WO claimed
US-4001388-A POLYESTERS ALZA CORPORATION (US) 1977-01-04 US claimed
US-3996386-A Method for preventing microbial surface deterioration of foods and feeds MALKKI YRJO 1976-12-07 US claimed
US-3995632-A Osmotic dispenser ALZA CORPORATION (US) 1976-12-07 US claimed
US-3983209-A HYDROPHOBIC BIOERODIBLE POLYMER, MICROBIOCIDE OR PROTEOLYTIC ENZYME ALZA CORPORATION (US) 1976-09-28 US claimed
US-3968201-A POLYMER PHARMACIA AKTIEBOLAG (SW) 1976-07-06 US claimed
US-3963579-A Microbiological process for the production of pepstatins SANRAKU-OCEAN CO., LTD. (JA) 1976-06-15 US claimed
US-3962436-A Pharmaceutical compositions having controlled rate of gastro-intestinal absorption SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1976-06-08 US claimed
US-3962414-A Structured bioerodible drug delivery device ALZA CORPORATION (US) 1976-06-08 US claimed
US-3960757-A HYDROPHOBIC TOYO JOZO CO., LTD. (JA) 1976-06-01 US claimed
US-3935309-A CHLORAMPHENICOL MERCK & CO., INC. (US) 1976-01-27 US claimed